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    ZFP37 ZFP37 zinc finger protein [ Homo sapiens (human) ]

    Gene ID: 7539, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZFP37provided by HGNC
    Official Full Name
    ZFP37 zinc finger proteinprovided by HGNC
    Primary source
    HGNC:HGNC:12863
    See related
    Ensembl:ENSG00000136866 MIM:602951; AllianceGenome:HGNC:12863
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF906; zfp-37
    Summary
    This gene encodes a transcription factor that belongs to a large family of zinc finger proteins. A similar protein in mouse is thought to play a role in regulating the structures of the nucleolus and centromere in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
    Expression
    Ubiquitous expression in ovary (RPKM 3.5), endometrium (RPKM 2.7) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZFP37 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (113038377..113056724, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (125191240..125228482, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (115800657..115819004, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene major urinary protein, pseudogene Neighboring gene zinc finger protein 883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:115838681-115839268 Neighboring gene OCT4 hESC enhancer GRCh37_chr9:115846570-115847071 Neighboring gene family with sequence similarity 225 member B Neighboring gene family with sequence similarity 225 member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    zinc finger protein 37 homolog
    Names
    zinc finger protein homologous to Zfp37 in mouse

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047087.2 RefSeqGene

      Range
      5000..23347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001282515.2NP_001269444.1  zinc finger protein 37 homolog isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI002852, AI005346, AK301275, AL162588, BC126390, DA738387
      Consensus CDS
      CCDS65110.1
      UniProtKB/Swiss-Prot
      Q9Y6Q3
      Related
      ENSP00000452552.1, ENST00000553380.1
      Conserved Domains (6) summary
      smart00349
      Location:47106
      KRAB; krueppel associated box
      COG5048
      Location:288633
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:450470
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:448470
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:4786
      KRAB; KRAB box
      pfam13465
      Location:462486
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001282518.2NP_001269447.1  zinc finger protein 37 homolog isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AI002852, AI005346, AL162588, BC144145
      Consensus CDS
      CCDS65109.1
      UniProtKB/Swiss-Prot
      Q9Y6Q3
      Related
      ENSP00000451310.1, ENST00000555206.5
      Conserved Domains (6) summary
      cd07765
      Location:3372
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:4592
      KRAB; krueppel associated box
      COG5048
      Location:274619
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:436456
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:434456
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:448472
      zf-H2C2_2; Zinc-finger double domain
    3. NM_003408.3NP_003399.1  zinc finger protein 37 homolog isoform 3

      See identical proteins and their annotated locations for NP_003399.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AI002852, AI005346, AL162588, BC126390
      Consensus CDS
      CCDS6787.1
      UniProtKB/Swiss-Prot
      A0AVJ9, B4DVX4, G3V3L7, Q5T7Q4, Q9Y6Q3
      Related
      ENSP00000363344.3, ENST00000374227.8
      Conserved Domains (6) summary
      cd07765
      Location:3371
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:4291
      KRAB; krueppel associated box
      COG5048
      Location:273618
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:435455
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:433455
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:447471
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      113038377..113056724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      125191240..125228482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363758.1XP_054219733.1  zinc finger protein 37 homolog isoform X2

    2. XM_054363757.1XP_054219732.1  zinc finger protein 37 homolog isoform X1