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    Clec4a4 C-type lectin domain family 4, member a4 [ Mus musculus (house mouse) ]

    Gene ID: 474145, updated on 9-Dec-2024

    Summary

    Official Symbol
    Clec4a4provided by MGI
    Official Full Name
    C-type lectin domain family 4, member a4provided by MGI
    Primary source
    MGI:MGI:3624119
    See related
    Ensembl:ENSMUSG00000059639 AllianceGenome:MGI:3624119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dcir2
    Summary
    Enables carbohydrate derivative binding activity. Predicted to be involved in several processes, including antifungal innate immune response; negative regulation of tumor necrosis factor production; and plasmacytoid dendritic cell antigen processing and presentation. Predicted to be active in external side of plasma membrane. Is expressed in ductus deferens; epididymis; and prostate gland. Orthologous to human CLEC4A (C-type lectin domain family 4 member A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See Clec4a4 in Genome Data Viewer
    Location:
    6 F2; 6 58.07 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (122967326..123001380)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122990367..123024421)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17264 Neighboring gene C-type lectin domain family 4, member a1 Neighboring gene C-type lectin domain family 4, member a3 Neighboring gene STARR-seq mESC enhancer starr_17268 Neighboring gene STARR-seq mESC enhancer starr_17269 Neighboring gene C-type lectin domain family 4, member b1 Neighboring gene C-type lectin domain family 4, member a2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC129456, MGC129457

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-mannose binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate derivative binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pattern recognition receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    C-type lectin domain family 4, member a4
    Names
    dendritic cell inhibitory receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005860.2NP_001005860.1  C-type lectin domain family 4, member a4

      See identical proteins and their annotated locations for NP_001005860.1

      Status: VALIDATED

      Source sequence(s)
      AY397673, BX524711
      Consensus CDS
      CCDS20509.1
      UniProtKB/TrEMBL
      Q5YIR8
      Related
      ENSMUSP00000078351.3, ENSMUST00000079379.3
      Conserved Domains (1) summary
      cd03590
      Location:107230
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      122967326..123001380
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)