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    MT1JP metallothionein 1J, pseudogene [ Homo sapiens (human) ]

    Gene ID: 4498, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MT1JPprovided by HGNC
    Official Full Name
    metallothionein 1J, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:7402
    See related
    Ensembl:ENSG00000290662 MIM:156356; AllianceGenome:HGNC:7402
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MT1; MTB; MT1J; MT1NP
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See MT1JP in Genome Data Viewer
    Location:
    16q13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (56635739..56637086)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (62430718..62432065)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56669651..56670998)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:56659379-56659915 Neighboring gene metallothionein 1E Neighboring gene metallothionein 1M Neighboring gene metallothionein 1A Neighboring gene metallothionein 1D, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Long noncoding RNA (lncRNA) metallothionein 1 J, pseudogene (MT1JP) is downregulated in triple-negative breast cancer and upregulates microRNA-138 (miR-138) to downregulate hypoxia-inducible factor-1α (HIF-1α). Wang G, et al. Bioengineered, 2022 May. PMID 35703312, Free PMC Article
    2. LncRNA MT1JP plays a protective role in intrahepatic cholangiocarcinoma by regulating miR-18a-5p/FBP1 axis. Zhao W, et al. BMC Cancer, 2021 Feb 8. PMID 33557774, Free PMC Article
    3. Long-Chain Non-Coding RNA (lncRNA) MT1JP Suppresses Biological Activities of Lung Cancer by Regulating miRNA-423-3p/Bim Axis. Ma J, et al. Med Sci Monit, 2019 Jul 10. PMID 31342947, Free PMC Article
    4. LncRNA MT1JP acts as a tumor inhibitor via reciprocally regulating Wnt/β-Catenin pathway in retinoblastoma. Bi LL, et al. Eur Rev Med Pharmacol Sci, 2018 Jul. PMID 30024609
    5. MT1JP-mediated miR-24-3p/BCL2L2 axis promotes Lenvatinib resistance in hepatocellular carcinoma cells by inhibiting apoptosis. Yu T, et al. Cell Oncol (Dordr), 2021 Aug. PMID 33974236, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long noncoding RNA (lncRNA) metallothionein 1 J, pseudogene (MT1JP) is downregulated in triple-negative breast cancer and upregulates microRNA-138 (miR-138) to downregulate hypoxia-inducible factor-1alpha (HIF-1alpha).
      Title: Long noncoding RNA (lncRNA) metallothionein 1 J, pseudogene (MT1JP) is downregulated in triple-negative breast cancer and upregulates microRNA-138 (miR-138) to downregulate hypoxia-inducible factor-1α (HIF-1α).
    2. MT1JP-mediated miR-24-3p/BCL2L2 axis promotes Lenvatinib resistance in hepatocellular carcinoma cells by inhibiting apoptosis.
      Title: MT1JP-mediated miR-24-3p/BCL2L2 axis promotes Lenvatinib resistance in hepatocellular carcinoma cells by inhibiting apoptosis.
    3. LncRNA MT1JP plays a protective role in intrahepatic cholangiocarcinoma by regulating miR-18a-5p/FBP1 axis.
      Title: LncRNA MT1JP plays a protective role in intrahepatic cholangiocarcinoma by regulating miR-18a-5p/FBP1 axis.
    4. Long Noncoding MT1JP Enhanced the Inhibitory Effects of miR-646 on FGF2 in Osteosarcoma.
      Title: Long Noncoding MT1JP Enhanced the Inhibitory Effects of miR-646 on FGF2 in Osteosarcoma.
    5. MT1JP, miRNA-423-3p, and Bim expressions in NSCLC cancer tissues and those in adjacent cancer tissues were significantly different (<i>P</i><0.01 or <i>P</i><0.001) with increasing stage.
      Title: Long-Chain Non-Coding RNA (lncRNA) MT1JP Suppresses Biological Activities of Lung Cancer by Regulating miRNA-423-3p/Bim Axis.
    6. Study results revealed that LncRNA MT1JP was down-regulated, while beta-catenin was highly expressed in retinoblastoma cells. Forced expression of MT1JP impaired the expression of the beta-catenin protein and its downstream targets such as cyclin D1, c-myc suggesting that MT1JP acting as a tumor suppressor in the development of retinoblastoma and might function as a prognostic biomarker.
      Title: LncRNA MT1JP acts as a tumor inhibitor via reciprocally regulating Wnt/β-Catenin pathway in retinoblastoma.
    7. LncRNA MT1JP was significantly lower in gastric cancer (GC) tissues than adjacent normal tissues, and higher MT1JP was remarkably related to lymph node metastasis and advance stage. lncRNA MT1JP acted as a competing endogenous RNA in regulating FBXW7 through sponging miR-92a-3p and inhibit cell proliferation, migration, invasion and promote cell apoptosis.
      Title: LncRNA MT1JP functions as a ceRNA in regulating FBXW7 through competitively binding to miR-92a-3p in gastric cancer.
    8. we identified MT1JP as a critical factor in restraining cell transformation by modulating p53 translation through interactions with TIAR
      Title: LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Other Names

    • metallothionein 1M pseudogene
    • metallothionein 1N, pseudogene
    • metallothionein B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_036677.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF348994
      Related
      ENST00000563395.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      56635739..56637086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      62430718..62432065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_005506.2: Suppressed sequence

      Description
      NG_005506.2: This RefSeq was permanently suppressed because it is now thought that this gene is a transcribed pseudogene.

    2. NM_175622.3: Suppressed sequence

      Description
      NM_175622.3: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version

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