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    PPP1R7 protein phosphatase 1 regulatory subunit 7 [ Homo sapiens (human) ]

    Gene ID: 5510, updated on 10-Dec-2024

    Summary

    Official Symbol
    PPP1R7provided by HGNC
    Official Full Name
    protein phosphatase 1 regulatory subunit 7provided by HGNC
    Primary source
    HGNC:HGNC:9295
    See related
    Ensembl:ENSG00000115685 MIM:602877; AllianceGenome:HGNC:9295
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SDS22
    Summary
    This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
    Expression
    Broad expression in testis (RPKM 40.9), brain (RPKM 18.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PPP1R7 in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (241149573..241183652)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (241648673..241683461)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242088988..242123067)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241949545-241950150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241950151-241950754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241957354-241957854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241957855-241958355 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57691 Neighboring gene SNED1 antisense RNA 1 Neighboring gene sushi, nidogen and EGF like domains 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241973517-241974460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241974461-241975402 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241975403-241976346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12526 Neighboring gene mitochondrial transcription termination factor 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242012857-242013373 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242040949-242041488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242041489-242042028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17414 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17415 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57723 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57727 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242079269-242079769 Neighboring gene PAS domain containing serine/threonine kinase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12530 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12531 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242097726-242098226 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:242106157-242106656 Neighboring gene uncharacterized LOC105373971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242125644-242126166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242127362-242128046 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242128047-242128730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242129664-242130164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242130165-242130665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242152515-242153074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242155713-242156244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17420 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57796 Neighboring gene anoctamin 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242163435-242164395 Neighboring gene uncharacterized LOC105376810 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:242175313-242175524 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:242189957-242190163 Neighboring gene high density lipoprotein binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12534 Neighboring gene HDLBP antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    protein phosphatase 1 regulatory subunit 7
    Names
    protein phosphatase 1 regulatory subunit 22
    protein phosphatase 1, regulatory (inhibitor) subunit 7
    testis secretory sperm-binding protein Li 210a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282409.1NP_001269338.1  protein phosphatase 1 regulatory subunit 7 isoform 2

      See identical proteins and their annotated locations for NP_001269338.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded protein (isoform 2, also known as sds22alpha2) is shorter compared to isoform 1.
      Source sequence(s)
      AC005237, BC051689, BM676947
      Consensus CDS
      CCDS63194.1
      UniProtKB/TrEMBL
      C9J177
      Related
      ENSP00000272983.8, ENST00000272983.12
      Conserved Domains (3) summary
      smart00446
      Location:293311
      LRRcap; occurring C-terminal to leucine-rich repeats
      sd00033
      Location:5778
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:44274
      internalin_A; class 1 internalin InlA
    2. NM_001282410.1NP_001269339.1  protein phosphatase 1 regulatory subunit 7 isoform 3

      See identical proteins and their annotated locations for NP_001269339.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' structure resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded protein (isoform 3, also known as sds22beta1) is shorter compared to isoform 1.
      Source sequence(s)
      AC005237, BC013001, BC051689
      Consensus CDS
      CCDS63192.1
      UniProtKB/Swiss-Prot
      Q15435
      Related
      ENSP00000385022.3, ENST00000406106.7
      Conserved Domains (2) summary
      COG4886
      Location:108272
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:100121
      LRR_RI; leucine-rich repeat [structural motif]
    3. NM_001282411.1NP_001269340.1  protein phosphatase 1 regulatory subunit 7 isoform 4

      See identical proteins and their annotated locations for NP_001269340.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks alternate exons in the coding region and uses an alternate 3' terminal exon compared to variant 1. The encoded protein (isoform 4, also known as sds22beta2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC005237, BC013001, BC051689, BG684153
      Consensus CDS
      CCDS63193.1
      UniProtKB/Swiss-Prot
      Q15435
      Related
      ENSP00000385466.1, ENST00000401987.5
      Conserved Domains (3) summary
      sd00033
      Location:5778
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:165207
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:165221
      LRR_8; Leucine rich repeat
    4. NM_001282412.1NP_001269341.1  protein phosphatase 1 regulatory subunit 7 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate 5' structure, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded protein (isoform 5) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC005237, AK308015, BC000910, BM676947, DA787059
      UniProtKB/TrEMBL
      H7C003
      Related
      ENSP00000392373.1, ENST00000450367.1
      Conserved Domains (3) summary
      sd00033
      Location:84105
      LRR_RI; leucine-rich repeat [structural motif]
      NF033188
      Location:65227
      internalin_H; InlH/InlC2 family class 1 internalin
      cd21340
      Location:147338
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    5. NM_001282413.1NP_001269342.1  protein phosphatase 1 regulatory subunit 7 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate 5' structure, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded protein (isoform 6) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC005237, AK308015, BC000910, BI256145, BM676947, DA787059
      UniProtKB/TrEMBL
      C9J177
      Related
      ENSP00000412092.1, ENST00000423280.5
      Conserved Domains (3) summary
      sd00033
      Location:4162
      LRR_RI; leucine-rich repeat [structural motif]
      NF033188
      Location:22184
      internalin_H; InlH/InlC2 family class 1 internalin
      cd21340
      Location:104295
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    6. NM_001282414.1NP_001269343.1  protein phosphatase 1 regulatory subunit 7 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' and 3' UTRs and has multiple coding region differences compared to variant 1. The encoded protein (isoform 7) is shorter and has distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC005237, BC013001, BQ212238, DA787059
      Consensus CDS
      CCDS63190.1
      UniProtKB/Swiss-Prot
      Q15435
      Related
      ENSP00000385012.1, ENST00000402734.5
      Conserved Domains (2) summary
      sd00033
      Location:4162
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:38213
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    7. NM_002712.3NP_002703.1  protein phosphatase 1 regulatory subunit 7 isoform 1

      See identical proteins and their annotated locations for NP_002703.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as sds22alpha1).
      Source sequence(s)
      AC005237, BC000910, BC051689, BM676947
      Consensus CDS
      CCDS2546.1
      UniProtKB/Swiss-Prot
      B4DFD4, B5MCY6, Q15435, Q9UQE5, Q9UQE6, Q9Y6K4
      UniProtKB/TrEMBL
      A0A140VK83, H7C003
      Related
      ENSP00000234038.6, ENST00000234038.11
      Conserved Domains (3) summary
      smart00446
      Location:336354
      LRRcap; occurring C-terminal to leucine-rich repeats
      sd00033
      Location:100121
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:87317
      internalin_A; class 1 internalin InlA

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      241149573..241183652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444851.1XP_047300807.1  protein phosphatase 1 regulatory subunit 7 isoform X2

      Related
      ENSP00000396376.1, ENST00000438799.5
    2. XM_011511388.3XP_011509690.1  protein phosphatase 1 regulatory subunit 7 isoform X1

      UniProtKB/TrEMBL
      C9J177
      Conserved Domains (3) summary
      smart00446
      Location:268286
      LRRcap; occurring C-terminal to leucine-rich repeats
      sd00033
      Location:3253
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:19249
      internalin_A; class 1 internalin InlA

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      241648673..241683461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342715.1XP_054198690.1  protein phosphatase 1 regulatory subunit 7 isoform X2

    2. XM_054342714.1XP_054198689.1  protein phosphatase 1 regulatory subunit 7 isoform X1

      UniProtKB/TrEMBL
      C9J177