PIP1;4 plasma membrane intrinsic protein 1;4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PIP1;4
Official Full Name: plasma membrane intrinsic protein 1;4
Primary source: TAIR:AT4G00430
Locus tag: AT4G00430
See related: Araport:AT4G00430
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: A_IG005I10.2; A_IG005I10_2; F5I10.2; F5I10_2; PIP1E; plasma membrane intrinsic protein 1;4; PLASMA MEMBRANE INTRINSIC PROTEIN 1E; TMP-C; TRANSMEMBRANE PROTEIN C
Summary: a member of the plasma membrane intrinsic protein subfamily PIP1.
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Genomic context

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See PIP1;4 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 4

Sequence:: Chromosome: 4; NC_003075.7 (185285..187680, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plasma Membrane Aquaporin Members PIPs Act in Concert to Regulate Cold Acclimation and Freezing Tolerance Responses in Arabidopsis thaliana.
Title: Plasma Membrane Aquaporin Members PIPs Act in Concert to Regulate Cold Acclimation and Freezing Tolerance Responses in Arabidopsis thaliana.
PIP1;4 functions as an effective facilitator of H2O2 transport across plasma membranes and mediates the translocation of externally applied H2O2 from the apoplast to the cytoplasm.PIP1;4 links pathogen-induced apoplastic H2O2 to the systemic acquired resistance pathway.
Title: Plant Aquaporin AtPIP1;4 Links Apoplastic H2O2 Induction to Disease Immunity Pathways.
Arabidopsis AtPIP1;4 is a plasma membrane sensor of Hpa1 and plays a dual role in plasma membrane permeability of CO2 and H2O.
Title: Harpin Hpa1 Interacts with Aquaporin PIP1;4 to Promote the Substrate Transport and Photosynthesis in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_116268.4

Supported by ESTs:

NM_202760.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables water channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to water deprivation	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within water transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: plasma membrane intrinsic protein 1;4

NP_567178.1

plasma membrane intrinsic protein 1;4 (PIP1;4); FUNCTIONS IN: water channel activity; INVOLVED IN: response to water deprivation, transport; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Major intrinsic protein, conserved site (InterPro:IPR022357), Aquaporin (InterPro:IPR012269), Major intrinsic protein (InterPro:IPR000425); BEST Arabidopsis thaliana protein match is: plasma membrane intrinsic protein 1B (TAIR:AT2G45960.1); Has 10702 Blast hits to 10683 proteins in 2216 species: Archae - 88; Bacteria - 5147; Metazoa - 1472; Fungi - 442; Plants - 2512; Viruses - 2; Other Eukaryotes - 1039 (source: NCBI BLink).

NP_974489.1

TRANSMEMBRANE PROTEIN C (TMP-C); FUNCTIONS IN: water channel activity; INVOLVED IN: response to water deprivation, transport; LOCATED IN: membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Major intrinsic protein, conserved site (InterPro:IPR022357), Major intrinsic protein (InterPro:IPR000425); BEST Arabidopsis thaliana protein match is: plasma membrane intrinsic protein 1B (TAIR:AT2G45960.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

185285..187680 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_116268.4 → NP_567178.1 plasma membrane intrinsic protein 1;4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567178.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O23059, O23829, Q39196

UniProtKB/TrEMBL

A0A178USZ7, A0A5S9XNK3, A0A7G2EV15

Conserved Domains (1) summary

pfam00230
Location:45 → 274

MIP; Major intrinsic protein
NM_202760.2 → NP_974489.1 plasma membrane intrinsic protein 1;4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974489.1

Status: REVIEWED

UniProtKB/TrEMBL

F4JHB6

Conserved Domains (1) summary

cl00200
Location:45 → 209

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...