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    FBXO36 F-box protein 36 [ Homo sapiens (human) ]

    Gene ID: 130888, updated on 3-Dec-2024

    Summary

    Official Symbol
    FBXO36provided by HGNC
    Official Full Name
    F-box protein 36provided by HGNC
    Primary source
    HGNC:HGNC:27020
    See related
    Ensembl:ENSG00000153832 MIM:609105; AllianceGenome:HGNC:27020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Fbx36
    Summary
    Members of the F-box protein family, such as FBXO36, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in thyroid (RPKM 4.9), testis (RPKM 3.7) and 24 other tissues See more
    Orthologs
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    Genomic context

    See FBXO36 in Genome Data Viewer
    Location:
    2q36.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (229922503..230013119)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (230405191..230495787)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (230787219..230877835)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene delta/notch like EGF repeat containing Neighboring gene uncharacterized LOC105373923 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230488203-230488702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:230579179-230579953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:230579954-230580727 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230591371-230591872 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:230608102-230608922 Neighboring gene MPRA-validated peak4073 silencer Neighboring gene thyroid hormone receptor interactor 12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:230714872-230715551 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:230715552-230716230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:230765063-230765564 Neighboring gene MPRA-validated peak4074 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230785780-230786280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17205 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230786281-230786781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17206 Neighboring gene RNA, U6 small nuclear 613, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230808542-230809042 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230817679-230818543 Neighboring gene uncharacterized LOC105373924 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:230829825-230830039 Neighboring gene RNA, U6 small nuclear 964, pseudogene Neighboring gene RNA, U6 small nuclear 1027, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:230871505-230871694 Neighboring gene uncharacterized LOC107985996 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:230910722-230911921 Neighboring gene solute carrier family 16 member 14 Neighboring gene RNY4 pseudogene 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174899.5NP_777559.3  F-box only protein 36

      See identical proteins and their annotated locations for NP_777559.3

      Status: VALIDATED

      Source sequence(s)
      AC009973, AK123085, BC017869, BC033935, BM997950
      Consensus CDS
      CCDS2472.1
      UniProtKB/Swiss-Prot
      B3KVQ6, Q53TE6, Q8NEA4, Q8WWD4
      UniProtKB/TrEMBL
      B8ZZQ1
      Related
      ENSP00000283946.3, ENST00000283946.8
      Conserved Domains (1) summary
      pfam12937
      Location:94140
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      229922503..230013119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005246317.3XP_005246374.1  F-box only protein 36 isoform X1

      UniProtKB/TrEMBL
      I6L982
      Conserved Domains (1) summary
      pfam12937
      Location:69115
      F-box-like; F-box-like

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      230405191..230495787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340598.1XP_054196573.1  F-box only protein 36 isoform X1

      UniProtKB/TrEMBL
      I6L982