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    ST6GALNAC4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 404124, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ST6GALNAC4provided by VGNC
    Official Full Name
    ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4provided by VGNC
    Primary source
    VGNC:VGNC:58614
    See related
    Ensembl:ENSBTAG00000046548
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    SIAT7B; ST6GALNAC2; st6GalNAc-IV
    Orthologs
    human mouse all
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    Genomic context

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    See ST6GALNAC4 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (98573693..98582863, complement)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene adenylate kinase 1 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase like 1 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 2, regulatory

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC143352

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ganglioside biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in oligosaccharide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase
    Names
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
    beta-galactosamide alpha-2,6-sialyltransferase
    NP_991360.1
    XP_005213234.1
    XP_005213235.1
    XP_005213236.1
    XP_005213237.1
    XP_015329086.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205791.1 → NP_991360.1  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase

      See identical proteins and their annotated locations for NP_991360.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ620651
      UniProtKB/TrEMBL
      A0AAA9TLQ5, Q704X4
      Related
      ENSBTAP00000099384.1, ENSBTAT00000088707.1
      Conserved Domains (1) summary
      pfam00777
      Location:59 → 289
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      98573693..98582863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005213180.5 → XP_005213237.1  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform X4

      See identical proteins and their annotated locations for XP_005213237.1

      UniProtKB/TrEMBL
      A0AAA9SYX4, Q0VC72
      Related
      ENSBTAP00000056350.1, ENSBTAT00000064279.3
      Conserved Domains (1) summary
      pfam00777
      Location:96 → 290
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_005213178.4 → XP_005213235.1  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform X2

      UniProtKB/TrEMBL
      A0AAA9SYX4
      Related
      ENSBTAP00000089481.1, ENSBTAT00000130719.1
      Conserved Domains (1) summary
      pfam00777
      Location:96 → 326
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. XM_005213179.5 → XP_005213236.1  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform X3

      UniProtKB/TrEMBL
      A0AAA9SYX4
      Conserved Domains (1) summary
      pfam00777
      Location:112 → 306
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. XM_005213177.4 → XP_005213234.1  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform X1

      UniProtKB/TrEMBL
      A0AAA9SYX4, G3N3B2
      Related
      ENSBTAP00000056414.3, ENSBTAT00000063122.3
      Conserved Domains (1) summary
      pfam00777
      Location:112 → 342
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    5. XM_015473600.3 → XP_015329086.1  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform X5

      Conserved Domains (1) summary
      pfam00777
      Location:112 → 286
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    Nucleotide Protein Strain
    Heading Accession and Version

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