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    • Showing Current items.

    myofl myoferlin like [ Danio rerio (zebrafish) ]

    Gene ID: 559066, updated on 9-Dec-2024

    Summary

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    Official Symbol
    myoflprovided by ZNC
    Official Full Name
    myoferlin likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-111116-2
    See related
    Ensembl:ENSDARG00000017128 AllianceGenome:ZFIN:ZDB-GENE-111116-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable metal ion binding activity. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Human ortholog(s) of this gene implicated in hereditary angioedema. Orthologous to human MYOF (myoferlin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See myofl in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    53
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (29238782..29289246)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (29108292..29158796)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member pge Neighboring gene unc-5 netrin receptor B Neighboring gene poly (ADP-ribose) glycohydrolase a Neighboring gene oxoglutarate dehydrogenase L Neighboring gene zgc:153142

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of vascular and hematopoietic genes downstream of etsrp by deep sequencing in zebrafish. Gomez G, et al. PLoS One, 2012. PMID 22438865, Free PMC Article
    2. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myoferlin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      29238782..29289246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_682373.10 → XP_687465.5  myoferlin

      UniProtKB/TrEMBL
      A0A8N7T5L8
      Related
      ENSDARP00000005170.8, ENSDART00000026000.9
      Conserved Domains (12) summary
      cd04011
      Location:202 → 311
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1131 → 1265
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:365 → 541
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1543 → 1666
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:5 → 136
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1779 → 1910
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:862 → 920
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:775 → 847
      FerB; FerB (NUC096) domain
      pfam08151
      Location:310 → 359
      FerI; FerI (NUC094) domain
      pfam08165
      Location:685 → 743
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1924 → 2038
      Ferlin_C; Ferlin C-terminus
      cl14603
      Location:1294 → 1396
      C2; C2 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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