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    dachd dachshund d [ Danio rerio (zebrafish) ]

    Gene ID: 791191, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dachdprovided by ZNC
    Official Full Name
    dachshund dprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070427-2
    See related
    Ensembl:ENSDARG00000069440 AllianceGenome:ZFIN:ZDB-GENE-070427-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:158869; si:ch211-176j8.3
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within glomerular filtration. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including immature eye; nervous system; neural tube; otic vesicle; and pronephros. Orthologous to human DACH1 (dachshund family transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dachd in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (30890549..31065163)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (31079803..31254411)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene Kruppel like factor 5b Neighboring gene uncharacterized LOC101887159 Neighboring gene uncharacterized LOC137496481 Neighboring gene G protein-coupled receptor 18 Neighboring gene G protein-coupled receptor 183a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Network-based identification and prioritization of key transcriptional factors of diabetic kidney disease. Ahmed I, et al. Comput Struct Biotechnol J, 2023. PMID 36659918, Free PMC Article
    2. The transcription factor Dach1 is essential for podocyte function. Endlich N, et al. J Cell Mol Med, 2018 May. PMID 29498212, Free PMC Article
    3. Whole-somite rotation generates muscle progenitor cell compartments in the developing zebrafish embryo. Hollway GE, et al. Dev Cell, 2007 Feb. PMID 17276339
    4. Investigating the role of dachshund b in the development of the pancreatic islet in zebrafish. Yang L, et al. J Diabetes Investig, 2021 May. PMID 33449448, Free PMC Article
    5. Dachshund homologues play a conserved role in islet cell development. Kalousova A, et al. Dev Biol, 2010 Dec 15. PMID 20869363, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dachshund d

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080673.1 → NP_001074142.1  dachshund d

      See identical proteins and their annotated locations for NP_001074142.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129504
      UniProtKB/TrEMBL
      A1L2G2
      Related
      ENSDARP00000091844.4, ENSDART00000101070.5
      Conserved Domains (2) summary
      pfam02437
      Location:88 → 188
      Ski_Sno; SKI/SNO/DAC family
      cl20817
      Location:478 → 531
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      30890549..31065163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167750.5 → XP_005167807.1  dachshund d isoform X2

      UniProtKB/TrEMBL
      A0A8M2BF69
      Conserved Domains (2) summary
      pfam02437
      Location:88 → 188
      Ski_Sno; SKI/SNO/DAC family
      cl20817
      Location:478 → 531
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. XM_005167749.5 → XP_005167806.1  dachshund d isoform X1

      UniProtKB/TrEMBL
      A0A8M2BF65
      Conserved Domains (2) summary
      pfam02437
      Location:88 → 188
      Ski_Sno; SKI/SNO/DAC family
      cl20817
      Location:477 → 530
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. XM_068223479.1 → XP_068079580.1  dachshund d isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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