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    aopep aminopeptidase O (putative) [ Danio rerio (zebrafish) ]

    Gene ID: 560737, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aopepprovided by ZNC
    Official Full Name
    aminopeptidase O (putative)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070410-115
    See related
    Ensembl:ENSDARG00000068461 AllianceGenome:ZFIN:ZDB-GENE-070410-115
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb974; wu:fa96d09; wu:fc79b08; zgc:162939
    Summary
    Predicted to enable metalloaminopeptidase activity and zinc ion binding activity. Predicted to act upstream of or within proteolysis. Predicted to be active in nucleolus. Is expressed in central nervous system; lateral line system; neural tube; pectoral fin; and tail bud. Human ortholog(s) of this gene implicated in dystonia 31. Orthologous to human AOPEP (aminopeptidase O (putative)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See aopep in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (30159329..30320535, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (30149333..30311378, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene patched 1 Neighboring gene FA complementation group C Neighboring gene microRNA mir-23b-2 Neighboring gene microRNA 24-3 Neighboring gene microRNA 27b Neighboring gene dedicator of cytokinesis 8 Neighboring gene COBW domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The Fanconi anemia gene network is conserved from zebrafish to human. Titus TA, et al. Gene, 2006 Apr 26. PMID 16515849
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC162939

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aminopeptidase O

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123258.1 → NP_001116730.1  aminopeptidase O

      See identical proteins and their annotated locations for NP_001116730.1

      Status: PROVISIONAL

      Source sequence(s)
      CR847548, CT027611
      UniProtKB/TrEMBL
      A0A8M2BF57, B0V1A5
      Related
      ENSDARP00000133501.1, ENSDART00000167065.3
      Conserved Domains (2) summary
      pfam09127
      Location:693 → 785
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
      cl14813
      Location:157 → 597
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      30159329..30320535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167175.5 → XP_005167232.1  aminopeptidase O isoform X1

      See identical proteins and their annotated locations for XP_005167232.1

      UniProtKB/TrEMBL
      A0A8M2BF57, B0V1A5
      Related
      ENSDARP00000098475.3, ENSDART00000111358.5
      Conserved Domains (2) summary
      pfam09127
      Location:693 → 785
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
      cl14813
      Location:157 → 597
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394730.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      357825..469137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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