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    cdk15 cyclin-dependent kinase 15 [ Danio rerio (zebrafish) ]

    Gene ID: 791619, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdk15provided by ZNC
    Official Full Name
    cyclin-dependent kinase 15provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060421-7193
    See related
    Ensembl:ENSDARG00000006093 AllianceGenome:ZFIN:ZDB-GENE-060421-7193
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:136819
    Summary
    Predicted to enable cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle phase transition. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytosol and nucleus. Orthologous to human CDK15 (cyclin dependent kinase 15). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cdk15 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (9747124..9791960, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (9511490..9558128, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene small ubiquitin like modifier 1 Neighboring gene frizzled class receptor 7b Neighboring gene uncharacterized LOC137495923 Neighboring gene alsin Rho guanine nucleotide exchange factor ALS2 b Neighboring gene uncharacterized LOC137495837 Neighboring gene MAGUK p55 scaffold protein 4b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC136819

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 15
    Names
    cell division protein kinase 15
    pftk2
    serine/threonine-protein kinase PFTAIRE-2
    NP_001035398.1
    XP_005165792.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040308.1 → NP_001035398.1  cyclin-dependent kinase 15

      See identical proteins and their annotated locations for NP_001035398.1

      Status: PROVISIONAL

      Source sequence(s)
      BC115279
      UniProtKB/Swiss-Prot
      Q1RLU9
      Related
      ENSDARP00000075572.4, ENSDART00000081129.5
      Conserved Domains (2) summary
      PLN00009
      Location:84 → 372
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07870
      Location:83 → 369
      STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      9747124..9791960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165735.5 → XP_005165792.1  cyclin-dependent kinase 15 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BD03
      Conserved Domains (2) summary
      PLN00009
      Location:127 → 415
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07870
      Location:126 → 412
      STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1RLU9.1 GenPept UniProtKB/Swiss-Prot:Q1RLU9

    Gene LinkOut

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