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    csnk1da casein kinase 1, delta a [ Danio rerio (zebrafish) ]

    Gene ID: 322106, updated on 9-Dec-2024

    Summary

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    Official Symbol
    csnk1daprovided by ZNC
    Official Full Name
    casein kinase 1, delta aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-825
    See related
    Ensembl:ENSDARG00000008370 AllianceGenome:ZFIN:ZDB-GENE-030131-825
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Csnk1d; csnk1dl; zgc:63971; wu:fb50c04
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including endocytosis; positive regulation of canonical Wnt signaling pathway; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within Wnt signaling pathway and protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; head; pectoral fin; post-vent region; and tail bud. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome 2. Orthologous to human CSNK1D (casein kinase 1 delta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See csnk1da in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (36173203..36210334, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (36043605..36080789, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene endo-beta-N-acetylglucosaminidase Neighboring gene solute carrier family 16 member 3a Neighboring gene dihydrouridine synthase 1-like (S. cerevisiae) Neighboring gene G protein pathway suppressor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish as model system for the biological characterization of CK1 inhibitors. Meier L, et al. Front Pharmacol, 2023. PMID 37753113, Free PMC Article
    2. Casein kinase 1δ activity: a key element in the zebrafish circadian timing system. Smadja Storz S, et al. PLoS One, 2013. PMID 23349822, Free PMC Article
    3. The CK1 gene family: expression patterning in zebrafish development. Albornoz A, et al. Biol Res, 2007. PMID 18064361
    4. The circadian clock of teleost fish: a comparative analysis reveals distinct fates for duplicated genes. Toloza-Villalobos J, et al. J Mol Evol, 2015 Jan. PMID 25487517
    5. Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain. Bolton CM, et al. Front Physiol, 2021. PMID 34925060, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that CK1delta inhibition abolishes rhythmic pineal aanat2 mRNA expression.
      Title: Casein kinase 1δ activity: a key element in the zebrafish circadian timing system.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of circadian rhythm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    casein kinase I isoform delta-A; casein kinase I
    Names
    CKI-delta-A
    CKId-A
    casein kinase 1, delta like
    NP_955877.1
    XP_005164045.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199583.1 → NP_955877.1  casein kinase I isoform delta-A

      See identical proteins and their annotated locations for NP_955877.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054583
      UniProtKB/Swiss-Prot
      Q7T2E3
      Related
      ENSDARP00000003101.6, ENSDART00000025326.7
      Conserved Domains (2) summary
      COG0515
      Location:9 → 380
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14125
      Location:8 → 282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      36173203..36210334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163988.5 → XP_005164045.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A286YAS3, A0A8M2BBB2
      Related
      ENSDARP00000144306.1, ENSDART00000175208.2
      Conserved Domains (2) summary
      COG0515
      Location:9 → 380
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14125
      Location:8 → 282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7T2E3.1 GenPept UniProtKB/Swiss-Prot:Q7T2E3

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