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    adgrl3.1 adhesion G protein-coupled receptor L3.1 [ Danio rerio (zebrafish) ]

    Gene ID: 560631, updated on 9-Dec-2024

    Summary

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    Official Symbol
    adgrl3.1provided by ZNC
    Official Full Name
    adhesion G protein-coupled receptor L3.1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7856
    See related
    Ensembl:ENSDARG00000061121 AllianceGenome:ZFIN:ZDB-GENE-030131-7856
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    lphn3; lphn3.1; wu:fj36g07; si:ch211-209p5.2
    Summary
    Predicted to enable G protein-coupled receptor activity and carbohydrate binding activity. Acts upstream of or within cellular response to estrogen stimulus; habituation; and locomotory exploration behavior. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; eye; heart; liver; and ovary. Orthologous to human ADGRL3 (adhesion G protein-coupled receptor L3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See adgrl3.1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (22943551..23157623, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (22252810..22467012, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene quinoid dihydropteridine reductase b, tandem duplicate 1 Neighboring gene general transcription factor IIE, polypeptide 2, beta Neighboring gene small integral membrane protein 18 Neighboring gene si:dkey-92j12.5 Neighboring gene replication factor C (activator 1) 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Novel non-stimulants rescue hyperactive phenotype in an adgrl3.1 mutant zebrafish model of ADHD. Sveinsdóttir HS, et al. Neuropsychopharmacology, 2023 Jul. PMID 36400921, Free PMC Article
    2. Pharmacological analysis of zebrafish lphn3.1 morphant larvae suggests that saturated dopaminergic signaling could underlie the ADHD-like locomotor hyperactivity. Lange M, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2018 Jun 8. PMID 29496512, Free PMC Article
    3. Developmental exposure to acetaminophen does not induce hyperactivity in zebrafish larvae. Reuter I, et al. J Neural Transm (Vienna), 2016 Aug. PMID 27116683
    4. adgrl3.1-deficient zebrafish show noradrenaline-mediated externalizing behaviors, and altered expression of externalizing disorder-candidate genes, suggesting functional targets for treatment. Fontana BD, et al. Transl Psychiatry, 2023 Oct 2. PMID 37783687, Free PMC Article
    5. An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility. Martinez AF, et al. Biol Psychiatry, 2016 Dec 15. PMID 27692237, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study found that lphn3.1 morphants have an overall hyposensitivity to dopamine agonists and antagonists compared to control fish. These results are compatible with a model whereby dopaminergic neurotransmission is saturated in lphn3.1 morphants.
      Title: Pharmacological analysis of zebrafish lphn3.1 morphant larvae suggests that saturated dopaminergic signaling could underlie the ADHD-like locomotor hyperactivity.
    2. results implicate decreased Lphn3 activity in eliciting ADHD-like behavior, and demonstrate its correlated contribution to the development of the brain dopaminergic circuitry
      Title: The ADHD-susceptibility gene lphn3.1 modulates dopaminergic neuron formation and locomotor activity during zebrafish development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within habituation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotory exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    latrophilin-3; adhesion G protein-coupled receptor L3
    Names
    latrophilin 3
    latrophilin 3.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      22943551..23157623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170941.5 → XP_005170998.1  adhesion G protein-coupled receptor L3 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BI50
      Conserved Domains (7) summary
      smart00284
      Location:160 → 415
      OLF; Olfactomedin-like domains
      smart00303
      Location:806 → 858
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:493 → 553
      HormR; Domain present in hormone receptors
      pfam00002
      Location:867 → 1102
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02140
      Location:66 → 146
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1123 → 1539
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 780
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    2. XM_684028.10 → XP_689120.5  adhesion G protein-coupled receptor L3 isoform X5

      UniProtKB/TrEMBL
      A0A2R8Q6E9, A0A8N7UUV2
      Related
      ENSDARP00000148668.1, ENSDART00000189344.1
      Conserved Domains (7) summary
      smart00284
      Location:160 → 415
      OLF; Olfactomedin-like domains
      smart00303
      Location:807 → 859
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:493 → 553
      HormR; Domain present in hormone receptors
      pfam00002
      Location:868 → 1103
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02140
      Location:66 → 146
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1124 → 1492
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 780
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    3. XM_021476346.2 → XP_021332021.1  adhesion G protein-coupled receptor L3 isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q934
      Conserved Domains (9) summary
      smart00284
      Location:160 → 415
      OLF; Olfactomedin-like domains
      smart00303
      Location:807 → 859
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:493 → 553
      HormR; Domain present in hormone receptors
      pfam02140
      Location:66 → 146
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1124 → 1498
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 782
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:870 → 894
      7tm_GPCRs; TM helix 1 [structural motif]
      cl26464
      Location:424 → 539
      Atrophin-1; Atrophin-1 family
      cl28897
      Location:867 → 1124
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_005170942.5 → XP_005170999.1  adhesion G protein-coupled receptor L3 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BI94, F1Q579
      Related
      ENSDARP00000081231.6, ENSDART00000086797.6
      Conserved Domains (7) summary
      smart00284
      Location:160 → 415
      OLF; Olfactomedin-like domains
      smart00303
      Location:807 → 859
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:493 → 553
      HormR; Domain present in hormone receptors
      pfam00002
      Location:868 → 1103
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02140
      Location:66 → 146
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1124 → 1534
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 780
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    5. XM_005170940.5 → XP_005170997.1  adhesion G protein-coupled receptor L3 isoform X1

      UniProtKB/TrEMBL
      A0A2R8QM07, A0A8M2BIN7
      Related
      ENSDARP00000156478.1, ENSDART00000190858.1
      Conserved Domains (7) summary
      smart00284
      Location:160 → 415
      OLF; Olfactomedin-like domains
      smart00303
      Location:807 → 859
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:493 → 553
      HormR; Domain present in hormone receptors
      pfam00002
      Location:868 → 1103
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02140
      Location:66 → 146
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1124 → 1540
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 780
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    Nucleotide Protein
    Heading Accession and Version

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