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    Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171138, updated on 27-Nov-2024

    Summary

    Official Symbol
    Kcne2provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily E regulatory subunit 2provided by RGD
    Primary source
    RGD:621383
    See related
    EnsemblRapid:ENSRNOG00000029811 AllianceGenome:RGD:621383
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mirp1
    Summary
    Enables several functions, including identical protein binding activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Contributes to delayed rectifier potassium channel activity and inward rectifier potassium channel activity. Involved in several processes, including potassium ion transmembrane transport; regulation of monoatomic ion transmembrane transporter activity; and tongue development. Located in cell surface and plasma membrane. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in atrial fibrillation; familial atrial fibrillation; long QT syndrome; and long QT syndrome 6. Orthologous to human KCNE2 (potassium voltage-gated channel subfamily E regulatory subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 96.3), Uterus (RPKM 33.0) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kcne2 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (45003468..45015942)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (31517176..31530026)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (32434786..32447264)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693540 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC102548079 Neighboring gene small integral membrane protein 11 Neighboring gene similar to human chromosome 21 open reading frame 140

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Clone Names

    • MGC108602

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to delayed rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to inward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to inward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoatomic cation channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane transporter binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cardiac muscle cell action potential involved in contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in iodide transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane repolarization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane repolarization during action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in membrane repolarization during action potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in membrane repolarization during action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane repolarization during ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in multicellular organismal response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myo-inositol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of delayed rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in potassium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cyclic nucleotide-gated ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of delayed rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of heart rate by cardiac conduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of membrane repolarization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ventricular cardiac muscle cell membrane repolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ventricular cardiac muscle cell membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tongue development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in ventricular cardiac muscle cell action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    potassium voltage-gated channel subfamily E member 2
    Names
    minK-related peptide 1
    minimum potassium ion channel-related peptide 1
    potassium channel subunit beta MiRP1
    potassium channel, voltage gated subfamily E regulatory beta subunit 2
    potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 2
    potassium voltage-gated channel, Isk-related family, member 2
    potassium voltage-gated channel, Isk-related subfamily, gene 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133603.2NP_598287.1  potassium voltage-gated channel subfamily E member 2

      See identical proteins and their annotated locations for NP_598287.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089778
      UniProtKB/Swiss-Prot
      P63161, Q5FVT9
      UniProtKB/TrEMBL
      A6JLI9
      Related
      ENSRNOP00000081079.1, ENSRNOT00000093948.2
      Conserved Domains (1) summary
      pfam02060
      Location:50108
      ISK_Channel; Slow voltage-gated potassium channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      45003468..45015942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)