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    uqcrc2b ubiquinol-cytochrome c reductase core protein 2b [ Danio rerio (zebrafish) ]

    Gene ID: 322549, updated on 9-Dec-2024

    Summary

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    Official Symbol
    uqcrc2bprovided by ZNC
    Official Full Name
    ubiquinol-cytochrome c reductase core protein 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1269
    See related
    Ensembl:ENSDARG00000071691 AllianceGenome:ZFIN:ZDB-GENE-030131-1269
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    uqcrc2; fi06a11; wu:fb64g04; wu:fi06a11
    Summary
    Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be active in mitochondrion. Is expressed in gut and liver. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 5. Orthologous to human UQCRC2 (ubiquinol-cytochrome c reductase core protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See uqcrc2b in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (10424679..10441639, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (10386836..10403796, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene transfer RNA leucine (anticodon UAG) Neighboring gene modulator of smoothened b Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein b (U4/U6.U5) Neighboring gene crystallin, mu

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish. Zou YY, et al. Front Endocrinol (Lausanne), 2023. PMID 37284220, Free PMC Article
    2. Mitochondrial DNA metabolism in early development of zebrafish (Danio rerio). Artuso L, et al. Biochim Biophys Acta, 2012 Jul. PMID 22465854
    3. Nucleoside supplementation modulates mitochondrial DNA copy number in the dguok -/- zebrafish. Munro B, et al. Hum Mol Genet, 2019 Mar 1. PMID 30428046, Free PMC Article
    4. A High-Fat Diet Induces Muscle Mitochondrial Dysfunction and Impairs Swimming Capacity in Zebrafish: A New Model of Sarcopenic Obesity. Zou YY, et al. Nutrients, 2022 May 9. PMID 35565942, Free PMC Article
    5. Altered glycometabolism in zebrafish exposed to thifluzamide. Yang Y, et al. Chemosphere, 2017 Sep. PMID 28535465

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome b-c1 complex subunit 2, mitochondrial
    Names
    ubiquinol-cytochrome c reductase core protein II
    ubiquinol-cytochrome c reductase core protein IIb
    NP_001001589.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001589.1 → NP_001001589.1  cytochrome b-c1 complex subunit 2, mitochondrial

      See identical proteins and their annotated locations for NP_001001589.1

      Status: PROVISIONAL

      Source sequence(s)
      BC071551
      UniProtKB/TrEMBL
      A0A8M1MZM2, Q6IQ59
      Related
      ENSDARP00000005930.7, ENSDART00000014379.8
      Conserved Domains (3) summary
      COG0612
      Location:39 → 432
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
      pfam00675
      Location:49 → 195
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:201 → 379
      Peptidase_M16_C; Peptidase M16 inactive domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      10424679..10441639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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