The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference assembly

Genomic

1. NZ_CP020121.1 Reference assembly

   Range

   1773368..1773841 complement

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   GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. WP_001389366.1 MULTISPECIES: trimethoprim-resistant dihydrofolate reductase DfrA17 [Pseudomonadota]

   See identical proteins and their annotated locations for WP_001389366.1

   UniProtKB/TrEMBL

   A0A059WGT9, A0A059WH46, A0A059WH72, A0A059WIA1, A0A059WMM9, A0A059WMS7, A0A088SAT6, A0A097DEP0, A0A0A0YWF1, A0A0A0YX39, A0A0A0Z004, A0A0A0Z1K7, A0A0A0Z1S6, A0A0A7DPL4, A0A0H3WFV8, A0A0M5KAK3, A0A0N7ER83, A0A0S1VX17, A0A191T6S0, A0A1B1LS32, A0A1S5TAM6, A0A1V0BEN7, A0A343UND9, A0A3T6J5I1, A0A4Y6MJB8, A0A5Z8ZC83, A0A6X7W3D0, A0A7I0KNP8, A0A9P2IY92, A0AA36L5N8, A0AA42L574, A0AA42Q9I4, A0AA44SHJ7, A0AAW9MCN0, A0AAX3AJM0, A4KTP9, A5JUM1, A7BID1, A7BID3, B2RGC8, B3WFP9, B7U9E8, B9X1G6, C3VUX4, C6G201, D0EZK2, D3UT52, D7PM77, H2B2M8, I3V621, I3VI63, I3VI82, Q689B1, Q75TK8, Q7BPP7, Q83ZN5, Q83ZN7, Q8G8M1, Q9R3C6, U3MYU9, U5YKY7

   Conserved Domains (1) summary

   cd00209
   Location:3 → 155

   DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...