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    Map3k5 mitogen-activated protein kinase kinase kinase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365057, updated on 9-Dec-2024

    Summary

    Official Symbol
    Map3k5provided by RGD
    Official Full Name
    mitogen-activated protein kinase kinase kinase 5provided by RGD
    Primary source
    RGD:1306565
    See related
    EnsemblRapid:ENSRNOG00000031700 AllianceGenome:RGD:1306565
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ask1; RGD1306565
    Summary
    Enables MAP kinase kinase kinase activity. Involved in several processes, including endothelial cell apoptotic process; positive regulation of MAPK cascade; and positive regulation of cardiac muscle cell apoptotic process. Located in external side of plasma membrane. Used to study cerebral infarction and myocardial infarction. Biomarker of membranous glomerulonephritis; transient cerebral ischemia; and visual epilepsy. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 130.0), Kidney (RPKM 130.0) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Map3k5 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (16505387..16723899)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (14685776..14904935)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (15412603..15613752)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484851 Neighboring gene uncharacterized LOC102547411 Neighboring gene small nucleolar RNA SNORA42/SNORA80 family Neighboring gene uncharacterized LOC102547350 Neighboring gene microtubule-associated protein 7 Neighboring gene uncharacterized LOC120098800 Neighboring gene uncharacterized LOC120098801

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables JUN kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MAP kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to reactive nitrogen species ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in endothelial cell apoptotic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron intrinsic apoptotic signaling pathway in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within programmed necrotic cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to endoplasmic reticulum stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ischemia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of IRE1-TRAF2-ASK1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 5
    Names
    apoptosis signal regulating kinase 1
    NP_001264623.1
    XP_038940750.1
    XP_038940753.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277694.1NP_001264623.1  mitogen-activated protein kinase kinase kinase 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6A280, A0A8I6AEL0
      Related
      ENSRNOP00000090845.1, ENSRNOT00000096116.2
      Conserved Domains (3) summary
      smart00220
      Location:692945
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06624
      Location:678945
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:172551
      DUF4071; Domain of unknown function (DUF4071)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      16505387..16723899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084822.2XP_038940750.1  mitogen-activated protein kinase kinase kinase 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A280, D3ZZH6
      Related
      ENSRNOP00000051338.6, ENSRNOT00000051496.8
      Conserved Domains (3) summary
      cd06624
      Location:678945
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:172552
      DUF4071; Domain of unknown function (DUF4071)
      pfam19039
      Location:562657
      ASK_PH; ASK kinase PH domain
    2. XM_039084825.2XP_038940753.1  mitogen-activated protein kinase kinase kinase 5 isoform X2

      Conserved Domains (1) summary
      cd06624
      Location:23290
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase