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    COPS2 COP9 signalosome subunit 2 [ Homo sapiens (human) ]

    Gene ID: 9318, updated on 9-Dec-2024

    Summary

    Official Symbol
    COPS2provided by HGNC
    Official Full Name
    COP9 signalosome subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:30747
    See related
    Ensembl:ENSG00000166200 MIM:604508; AllianceGenome:HGNC:30747
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSN2; SGN2; ALIEN; TRIP15
    Summary
    Predicted to enable transcription corepressor activity. Involved in protein deneddylation and protein phosphorylation. Located in cytoplasm. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 22.3), thyroid (RPKM 19.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See COPS2 in Genome Data Viewer
    Location:
    15q21.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (49122727..49155599, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (46930938..46963811, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (49414924..49447796, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene SECIS binding protein 2 like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9384 Neighboring gene RNA, 7SL, cytoplasmic 577, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:49357796-49358296 Neighboring gene uncharacterized LOC124903489 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:49447830-49448748 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4 pseudogene 1 Neighboring gene galactokinase 2 Neighboring gene microRNA 4716

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr is identified to have a physical interaction with COP9 constitutive photomorphogenic homolog subunit 2 (COPS2; CSN2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in inner cell mass cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein deneddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein deneddylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein neddylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein neddylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in skeletal muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in trophectodermal cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of COP9 signalosome IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of COP9 signalosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    COP9 signalosome complex subunit 2
    Names
    COP9 constitutive photomorphogenic homolog subunit 2
    JAB1-containing signalosome subunit 2
    TR-interacting protein 15
    TRIP-15
    alien homolog
    signalosome subunit 2
    thyroid receptor-interacting protein 15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143887.2NP_001137359.1  COP9 signalosome complex subunit 2 isoform 2

      See identical proteins and their annotated locations for NP_001137359.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AB209799, AC013452, BM667648, BX648602, CN281648, DB059510
      Consensus CDS
      CCDS45257.1
      UniProtKB/TrEMBL
      Q59EL2
      Related
      ENSP00000299259.6, ENST00000299259.10
      Conserved Domains (2) summary
      COG5159
      Location:40441
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:316420
      PCI; PCI domain
    2. NM_004236.4NP_004227.1  COP9 signalosome complex subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_004227.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has an exon with an alternative splice acceptor site in the 5' coding region, compared to variant 2, which results in a shorter protein (isoform 1), compared to isoform 2.
      Source sequence(s)
      AC013452, BC012629, BM667648, BX648602, CN281648, CN287009, DB059510
      Consensus CDS
      CCDS32235.1
      UniProtKB/Swiss-Prot
      O88950, P61201, Q15647, Q6FGP4, Q9BY54, Q9R249, Q9UNI2, Q9UNQ5
      UniProtKB/TrEMBL
      B2R6N0, Q53HJ0
      Related
      ENSP00000373553.5, ENST00000388901.10
      Conserved Domains (2) summary
      COG5159
      Location:40434
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:309413
      PCI; PCI domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      49122727..49155599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      46930938..46963811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)