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    ewsr1b EWS RNA-binding protein 1b [ Danio rerio (zebrafish) ]

    Gene ID: 322880, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ewsr1bprovided by ZNC
    Official Full Name
    EWS RNA-binding protein 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1600
    See related
    Ensembl:ENSDARG00000020465 AllianceGenome:ZFIN:ZDB-GENE-030131-1600
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fusl; fb40b11; zgc:55864; wu:fb40b11; wu:fb75g09
    Summary
    Predicted to enable RNA binding activity and transcription coregulator activity. Acts upstream of or within central nervous system neuron development and mitotic cell cycle. Predicted to be active in nucleus. Is expressed in fin bud; gut; nervous system; and trunk. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ewsr1b in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (24873560..24882357, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (24369760..24378557, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 1 subunit beta 1 Neighboring gene growth arrest-specific 2 like 1 Neighboring gene rhomboid domain containing 3 Neighboring gene EMI domain containing 1 Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ewing sarcoma protein ewsr1 maintains mitotic integrity and proneural cell survival in the zebrafish embryo. Azuma M, et al. PLoS One, 2007 Oct 3. PMID 17912356, Free PMC Article
    2. Regulation of zebrafish dorsoventral patterning by phase separation of RNA-binding protein Rbm14. Xiao Y, et al. Cell Discov, 2019. PMID 31636951, Free PMC Article
    3. Characterization of genetic loss-of-function of Fus in zebrafish. Lebedeva S, et al. RNA Biol, 2017 Jan 2. PMID 27898262, Free PMC Article
    4. ALS-associated genes display CNS expression in the developing zebrafish. Laboissonniere LA, et al. Gene Expr Patterns, 2018 Dec. PMID 30165106
    5. Transcriptome kinetics of arsenic-induced adaptive response in zebrafish liver. Lam SH, et al. Physiol Genomics, 2006 Nov 27. PMID 16882884

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development
      Title: Ewing sarcoma protein ewsr1 maintains mitotic integrity and proneural cell survival in the zebrafish embryo.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55864

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    EWS RNA-binding protein 1b
    Names
    Ewing sarcoma breakpoint region 1b
    fusion, derived from t(12;16) malignant liposarcoma, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212630.1 → NP_997795.1  EWS RNA-binding protein 1b

      See identical proteins and their annotated locations for NP_997795.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044518
      UniProtKB/TrEMBL
      A0A8M1PHA4, Q803E3
      Related
      ENSDARP00000110206.2, ENSDART00000127773.4
      Conserved Domains (4) summary
      COG0724
      Location:305 → 396
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      sd00025
      Location:459 → 480
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:455 → 485
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl17169
      Location:311 → 394
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      24873560..24882357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165108.3 → XP_005165165.2  EWS RNA-binding protein 1b isoform X2

      UniProtKB/TrEMBL
      A0A8M2BCF1
      Conserved Domains (4) summary
      COG0724
      Location:304 → 395
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      sd00025
      Location:458 → 479
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:454 → 484
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl17169
      Location:310 → 393
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_005165107.3 → XP_005165164.2  EWS RNA-binding protein 1b isoform X1

      See identical proteins and their annotated locations for XP_005165164.2

      UniProtKB/TrEMBL
      A0A8M2BCA1, Q4QRG0
      Related
      ENSDARP00000002269.8, ENSDART00000003998.10
      Conserved Domains (4) summary
      COG0724
      Location:306 → 397
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      sd00025
      Location:460 → 481
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:456 → 486
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl17169
      Location:312 → 395
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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