lasp1 LIM and SH3 protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lasp1provided by ZNC
Official Full Name: LIM and SH3 protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1936
See related: Ensembl:ENSDARG00000057867 AllianceGenome:ZFIN:ZDB-GENE-030131-1936
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb92f05; zgc:77542; wu:fb92f05
Summary: Predicted to enable actin filament binding activity. Predicted to act upstream of or within monoatomic ion transport. Predicted to be located in cell cortex and cytoskeleton. Predicted to be active in focal adhesion. Is expressed in brain; digestive system; eye; muscle; and trunk. Orthologous to human LASP1 (LIM and SH3 protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (16072972..16109815, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (15923172..15960015, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lasp1 Expression Is Implicated in Embryonic Development of Zebrafish.
Title: Lasp1 Expression Is Implicated in Embryonic Development of Zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: LIM and SH3 domain protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212636.1 → NP_997801.1 LIM and SH3 domain protein 1

See identical proteins and their annotated locations for NP_997801.1

Status: PROVISIONAL

Source sequence(s)

BC066574

UniProtKB/TrEMBL

A9JT31, F6P5I6, Q6NYJ1

Related

ENSDARP00000051806.4, ENSDART00000051807.6

Conserved Domains (3) summary

smart00227
Location:98 → 128

NEBU; The Nebulin repeat is present also in Las1

cd09447
Location:5 → 57

LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)

cd11934
Location:176 → 234

SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1