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    eif2s2 eukaryotic translation initiation factor 2, subunit 2 beta [ Danio rerio (zebrafish) ]

    Gene ID: 324365, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eif2s2provided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 2, subunit 2 betaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3085
    See related
    Ensembl:ENSDARG00000053047 AllianceGenome:ZFIN:ZDB-GENE-030131-3085
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:77084; wu:fc26g03; wu:fu10f07
    Summary
    Predicted to enable mRNA binding activity; translation initiation factor activity; and translation initiation factor binding activity. Predicted to be involved in formation of translation preinitiation complex. Predicted to act upstream of or within translational initiation. Predicted to be part of eukaryotic translation initiation factor 2 complex. Orthologous to human EIF2S2 (eukaryotic translation initiation factor 2 subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See eif2s2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (49995781..50011926)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (49997128..50013273)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496021 Neighboring gene agouti signaling protein 1 Neighboring gene RALY heterogeneous nuclear ribonucleoprotein Neighboring gene uncharacterized LOC101886784

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish GAPDH can be used as a reference gene for expression analysis in cross-subfamily cloned embryos. Pei DS, et al. Anal Biochem, 2007 Apr 15. PMID 17239340
    2. GH overexpression causes muscle hypertrophy independent from local IGF-I in a zebrafish transgenic model. Kuradomi RY, et al. Transgenic Res, 2011 Jun. PMID 20640508
    3. Evaluation of qPCR reference genes in GH-overexpressing transgenic zebrafish (Danio rerio). Rassier GT, et al. Sci Rep, 2020 Jul 29. PMID 32728128, Free PMC Article
    4. BAC Recombineering of the Agouti Loci from Spotted Gar and Zebrafish Reveals the Evolutionary Ancestry of Dorsal-Ventral Pigment Asymmetry in Fish. Cal L, et al. J Exp Zool B Mol Dev Evol, 2017 Nov. PMID 28544213, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of eukaryotic translation initiation factor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2 subunit 2
    Names
    eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212675.1 → NP_997840.1  eukaryotic translation initiation factor 2 subunit 2

      See identical proteins and their annotated locations for NP_997840.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066706
      UniProtKB/TrEMBL
      Q6NY78
      Related
      ENSDARP00000069494.2, ENSDART00000075009.3
      Conserved Domains (1) summary
      smart00653
      Location:193 → 302
      eIF2B_5; domain present in translation initiation factor eIF2B and eIF5

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      49995781..50011926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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