Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ugt1a7cprovided by MGI
Official Full Name: UDP glucuronosyltransferase 1 family, polypeptide A7Cprovided by MGI
Primary source: MGI:MGI:3032636
See related: Ensembl:ENSMUSG00000090124 AllianceGenome:MGI:3032636
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A13; A10'; UGT1A7; Ugt1a10
Summary: Predicted to enable several functions, including monocarboxylic acid binding activity; protein dimerization activity; and protein kinase C binding activity. Predicted to be involved in several processes, including cellular glucuronidation; coumarin catabolic process; and estrogen catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in nervous system; stomach; and urinary system. Human ortholog(s) of this gene implicated in alcoholic pancreatitis and pancreatic cancer. Orthologous to several human genes including UGT1A10 (UDP glucuronosyltransferase family 1 member A10); UGT1A7 (UDP glucuronosyltransferase family 1 member A7); and UGT1A8 (UDP glucuronosyltransferase family 1 member A8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in kidney adult (RPKM 238.8), liver adult (RPKM 142.7) and 10 other tissues See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1 D; 1 44.5 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (88022723..88147724)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (88095001..88220002)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables glucuronosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glucuronosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables retinoic acid binding	ISO Inferred from Sequence Orthology more info
enables steroid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular glucuronidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular glucuronidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in coumarin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in liver development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: UDP-glucuronosyltransferase 1A7

Names: UDP glucuronosyltransferase 1 family, polypeptide A10; UDP glycosyltransferase 1 family, polypeptide A10; UDP-glucuronosyltransferase 1-7C; UDP-glucuronosyltransferase 1A7C; UDPGT 1-7C; UGT1*7C; UGT1-07C; UGT1.7C

NP_964004.1

EC 2.4.1.17

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201642.4 → NP_964004.1 UDP-glucuronosyltransferase 1A7 precursor

See identical proteins and their annotated locations for NP_964004.1

Status: VALIDATED

Source sequence(s)

AC087801, AK159496, AK165465

Consensus CDS

CCDS15139.1

UniProtKB/Swiss-Prot

B2RUL6, Q6XL45, Q6ZQM8

Related

ENSMUSP00000058683.8, ENSMUST00000058237.14

Conserved Domains (2) summary

PHA03392
Location:225 → 503

egt; ecdysteroid UDP-glucosyltransferase; Provisional

pfam00201
Location:26 → 522

UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase