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    PHB1 prohibitin 1 [ Homo sapiens (human) ]

    Gene ID: 5245, updated on 27-Nov-2024

    Summary

    Official Symbol
    PHB1provided by HGNC
    Official Full Name
    prohibitin 1provided by HGNC
    Primary source
    HGNC:HGNC:8912
    See related
    Ensembl:ENSG00000167085 MIM:176705; AllianceGenome:HGNC:8912
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PHB; BAP32; HEL-215; HEL-S-54e
    Summary
    This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
    Expression
    Ubiquitous expression in kidney (RPKM 68.3), colon (RPKM 44.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PHB1 in Genome Data Viewer
    Location:
    17q21.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (49404052..49414882, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (50267083..50277908, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47481414..47492244, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 652 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12360 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8668 Neighboring gene ZNF652 antisense RNA 1 Neighboring gene ribosomal protein L21 pseudogene 124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12361 Neighboring gene eukaryotic translation initiation factor 4E pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12362 Neighboring gene long intergenic non-protein coding RNA 2075

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies eight loci associated with blood pressure.
    EBI GWAS Catalog
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify prohibitin (PHB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    env HIV-1 gp120 upregulates the expression of prohibitin in umbilical cord blood mononuclear cells and T-cell lines PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with prohibitin 1 (PHB1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    env The C-terminal cytoplasmic domain (Env-CT) of HIV-1 Env specifically binds to the Phb1/Phb2 complex. Strong binding is dependent on Env residues 790-800. L799R/L800Q double mutation in Env severely inhibits its binding to the Phb1/Phb2 complex PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with prohibitin (PHB) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify prohibitin (PHB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify prohibitin (PHB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify prohibitin (PHB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Tat tat Expression of HIV-1 Tat upregulates the abundance of prohibitin (PHB) in the nucleoli of Jurkat T-cells PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of prohibitin (PHB) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    vpr The proteomic assay from Vpr-expressing HTLV-1 transformed cells reveals apoptosis related protein changes, such as mitochondrial protein prohibitin PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables complement component C3a binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables complement component C3b binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables proteinase activated receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in RIG-I signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in T-helper 17 type immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antiviral innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to interleukin-6 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epigenetic regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrion organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in modulation by host of viral RNA genome replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of androgen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of glucocorticoid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by competitive promoter binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in osteoblast differentiation HDA PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of complement activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of immunoglobulin production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-17 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of positive regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in progesterone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in symbiont entry into host cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    prohibitin 1
    Names
    epididymis luminal protein 215
    epididymis secretory sperm binding protein Li 54e
    prohibitin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023046.2 RefSeqGene

      Range
      5000..15830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001281496.2NP_001268425.1  prohibitin 1 isoform 1

      See identical proteins and their annotated locations for NP_001268425.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2 and 4 encode the same isoform (1).
      Source sequence(s)
      AC091180
      Consensus CDS
      CCDS11548.1
      UniProtKB/Swiss-Prot
      B4DY47, P35232, Q4VBQ0
      UniProtKB/TrEMBL
      A8K401, Q53FV0, Q6PUJ7
      Related
      ENSP00000484113.1, ENST00000617874.5
      Conserved Domains (1) summary
      cd03401
      Location:27221
      SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    2. NM_001281497.2NP_001268426.1  prohibitin 1 isoform 2

      See identical proteins and their annotated locations for NP_001268426.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses alternate in-frame splice sites and lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      AC091180
      Consensus CDS
      CCDS62244.1
      UniProtKB/Swiss-Prot
      P35232
      Related
      ENSP00000512581.1, ENST00000696365.1
      Conserved Domains (1) summary
      cd03401
      Location:27141
      SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    3. NM_001281715.2NP_001268644.1  prohibitin 1 isoform 1

      See identical proteins and their annotated locations for NP_001268644.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
      Source sequence(s)
      AC091180
      Consensus CDS
      CCDS11548.1
      UniProtKB/Swiss-Prot
      B4DY47, P35232, Q4VBQ0
      UniProtKB/TrEMBL
      A8K401, Q53FV0, Q6PUJ7
      Related
      ENSP00000479488.1, ENST00000614445.5
      Conserved Domains (1) summary
      cd03401
      Location:27221
      SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    4. NM_002634.4NP_002625.1  prohibitin 1 isoform 1

      See identical proteins and their annotated locations for NP_002625.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
      Source sequence(s)
      AC091180
      Consensus CDS
      CCDS11548.1
      UniProtKB/Swiss-Prot
      B4DY47, P35232, Q4VBQ0
      UniProtKB/TrEMBL
      A8K401, Q53FV0, Q6PUJ7
      Related
      ENSP00000300408.3, ENST00000300408.8
      Conserved Domains (1) summary
      cd03401
      Location:27221
      SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      49404052..49414882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024763.2XP_016880252.1  prohibitin 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DY47, P35232, Q4VBQ0
      UniProtKB/TrEMBL
      A8K401, Q53FV0, Q6PUJ7
      Conserved Domains (1) summary
      cd03401
      Location:27221
      SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      50267083..50277908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316505.1XP_054172480.1  prohibitin 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DY47, P35232, Q4VBQ0
      UniProtKB/TrEMBL
      A8K401