tafazzin tafazzin, phospholipid-lysophospholipid transacylase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tafazzinprovided by ZNC
Official Full Name: tafazzin, phospholipid-lysophospholipid transacylaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-684
See related: Ensembl:ENSDARG00000041421 AllianceGenome:ZFIN:ZDB-GENE-030131-684
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: taz; zgc:91803; wu:fb39f12
Summary: Predicted to enable 1-acylglycerophosphocholine O-acyltransferase activity. Acts upstream of or within heart looping and positive regulation of heart contraction. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrial membrane. Is expressed in several structures, including endoderm; head; liver; ovary; and pericardial region. Used to study Barth syndrome and visceral heterotaxy. Human ortholog(s) of this gene implicated in Barth syndrome and dilated cardiomyopathy. Orthologous to human TAFAZZIN (tafazzin, phospholipid-lysophospholipid transacylase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (4915992..4925640, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (4980381..4990082, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disrupted gene function in yap1(-/-); taz(+/-) embryos did not disturb liver bud formation, but instead impaired cell proliferation in liver and movement of the neighboring lateral plate mesoderm (LPM). Overexpression of wild type yap1 or taz could rescue the defective liver phenotypes in yap1(-/-); taz(+/-) embryos.
Title: Yap1/Taz are essential for the liver development in zebrafish.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
Title: Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization.
knockdown phenotype demonstrates that abnormal cardiac development, with a linear, nonlooped heart, and hypomorphic tail and eye development proves that tafazzin is essential for overall zebrafish development, especially of the heart.
Title: A zebrafish model of human Barth syndrome reveals the essential role of tafazzin in cardiac development and function.

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General gene information

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Markers

fc23d08.x1 (e-PCR)
- UniSTS:193148

fb51h10.x1 (e-PCR)
- UniSTS:190661

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cardiolipin acyl-chain remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiolipin metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner mitochondrial membrane organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in mitophagy	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tafazzin

NP_001001814.1

EC 2.3.1.-

XP_009294889.1

EC 2.3.1.-

XP_068072774.1

EC 2.3.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001814.1 → NP_001001814.1 tafazzin

See identical proteins and their annotated locations for NP_001001814.1

Status: PROVISIONAL

Source sequence(s)

AY576995

UniProtKB/Swiss-Prot

F1QCP6, Q6PUS0

Related

ENSDARP00000120241.1, ENSDART00000140861.3

Conserved Domains (1) summary

cd07989
Location:34 → 241

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007134.7 Reference GRCz11 Primary Assembly

Range

4915992..4925640 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009296614.3 → XP_009294889.1 tafazzin isoform X1

UniProtKB/Swiss-Prot

F1QCP6, Q6PUS0

UniProtKB/TrEMBL

A0A8M3AV28

Conserved Domains (1) summary

cd07989
Location:34 → 238

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
XM_068216673.1 → XP_068072774.1 tafazzin isoform X2

Related

ENSDART00000139758.3