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    Prosalpha4T2 Proteasome alpha4 subunit, Testis-specific 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37910, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prosalpha4T2provided by FlyBase
    Official Full Name
    Proteasome alpha4 subunit, Testis-specific 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0017556
    Locus tag
    Dmel_CG4569
    See related
    AllianceGenome:FB:FBgn0017556
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    a4-t2; alpha4t2; alpha4T2; alpha4t2_dm; CG4569; dalpha7; Dmel\CG4569; pros28.1B; Pros28.1B
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome core complex, alpha-subunit complex. Predicted to be active in nucleus. Orthologous to human PSMA7 (proteasome 20S subunit alpha 7) and PSMA8 (proteasome 20S subunit alpha 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prosalpha4T2 in Genome Data Viewer
    Location:
    60D1-60D1; 2-107 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24500780..24502277, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20388303..20389800, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:Yu Neighboring gene Suppressor of Stellate-like Neighboring gene uncharacterized protein Neighboring gene Leucine zipper and EF-hand containing transmembrane protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. Klein U, et al. J Cell Biol, 1990 Dec. PMID 2126012, Free PMC Article
    2. Duplicated proteasome subunit genes in Drosophila melanogaster encoding testes-specific isoforms. Yuan X, et al. Genetics, 1996 Sep. PMID 8878681, Free PMC Article
    3. Evolutionary conservation of a testes-specific proteasome subunit gene in Drosophila. Belote JM, et al. Gene, 1998 Jul 17. PMID 9666090
    4. Analysis of the Drosophila melanogaster testes transcriptome reveals coordinate regulation of paralogous genes. Mikhaylova LM, et al. Genetics, 2008 May. PMID 18493055, Free PMC Article
    5. Molecular cloning of the Drosophila melanogaster gene alpha5_dm encoding a 20S proteasome alpha-type subunit. Zaiss D, et al. Gene, 1997 Nov 12. PMID 9409776

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proteasome alpha4 subunit, Testis-specific 2
    Names
    20s proteasome
    CG4569-PA
    CG4569-PB
    Pros28.1B
    Prosalpha4T2-PA
    Prosalpha4T2-PB
    proteasome 28kD subunit 1B
    proteasome alpha 4 subunit, Testis-specific 2
    testes-specific proteasome subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24500780..24502277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299915.1 → NP_001286844.1  proteasome alpha4 subunit, Testis-specific 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286844.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27575, Q6QH11, Q8T3X2, Q9W162
      UniProtKB/TrEMBL
      A0A0B4LHK2, I7DL49
      Conserved Domains (2) summary
      TIGR03633
      Location:5 → 215
      arc_protsome_A; proteasome endopeptidase complex, archaeal, alpha subunit
      cl00467
      Location:5 → 214
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

    2. NM_138076.4 → NP_611920.1  proteasome alpha4 subunit, Testis-specific 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611920.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27575, Q6QH11, Q8T3X2, Q9W162
      UniProtKB/TrEMBL
      A0A0B4LHK2, I7DL49
      Related
      FBpp0072257
      Conserved Domains (2) summary
      TIGR03633
      Location:5 → 215
      arc_protsome_A; proteasome endopeptidase complex, archaeal, alpha subunit
      cl00467
      Location:5 → 214
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHK2 A0A0B4LHK2
    Q27575.2 Q27575

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