atp5if1a ATP synthase inhibitory factor subunit 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: atp5if1aprovided by ZNC
Official Full Name: ATP synthase inhibitory factor subunit 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070410-36
See related: Ensembl:ENSDARG00000067975 AllianceGenome:ZFIN:ZDB-GENE-070410-36
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: IF1 A; atpif1; IF(1) A; atpif1a; zgc:162207
Summary: Predicted to enable ATPase binding activity; ATPase inhibitor activity; and protein homodimerization activity. Involved in erythrocyte differentiation and heme biosynthetic process. Acts upstream of or within optokinetic behavior; regulation of neuroinflammatory response; and visual perception. Predicted to be active in mitochondrion. Is expressed in blood and common myeloid progenitor. Used to study blindness. Orthologous to human ATP5IF1 (ATP synthase inhibitory factor subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (84052..85579, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (83962..85489, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study unveils a functional relay between IF1 and optic atrophy 1 in central nervous system.
Title: Reduction of the ATPase inhibitory factor 1 (IF(1)) leads to visual impairment in vertebrates.
the identification of mitochondrial Atpif1 as a regulator of haem synthesis advances our understanding of the mechanisms regulating mitochondrial haem homeostasis and red blood cell development
Title: Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATPase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables ATPase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in erythrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heme biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heme biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of ATP-dependent activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitochondrial ATP synthesis coupled proton transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within optokinetic behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of neuroinflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATPase inhibitor A, mitochondrial

Names: ATP synthase F1 subunit epsilon A; ATPase inhibitory factor 1; ATPase inhibitory factor 1a; inhibitor of F(1)F(o)-ATPase A; pnt; protein pinotage

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.