lqf liquid facets [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: lqfprovided by FlyBase
Official Full Name: liquid facetsprovided by FlyBase
Primary source: FLYBASE:FBgn0028582
Locus tag: Dmel_CG8532
See related: AllianceGenome:FB:FBgn0028582
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0110/27; anon-WO0118547.239; CG8532; dEpsin; Dmel\CG8532; E(faf)bE25; epsin; Epsin; Iqf; l(3)S011027; Lqf; LqF
Summary: Predicted to enable clathrin binding activity and phospholipid binding activity. Involved in several processes, including clathrin-dependent endocytosis; negative regulation of cardioblast cell fate specification; and positive regulation of signal transduction. Located in nuclear periphery; synaptic membrane; and vacuole. Is expressed in embryonic/larval hypodermal muscle cell; embryonic/larval motor neurons; embryonic/larval tracheal section; eye disc; and organism. Orthologous to several human genes including EPN1 (epsin 1) and EPN2 (epsin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 66A4-66A5; 3-21 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (7528780..7540012)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (7521880..7533112)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DSL ligands activate Notch by inducing proteolytic cleavage of the receptor ectodomain that requires ligand to be endocytosed in signal-sending cells by the adaptor protein Epsin; results suggest that once ligand binds receptor, activation depends on a competition between Epsin-mediated ligand endocytosis, which induces cleavage, and transendocytosis of the ligand by the receptor, which aborts the incipient signal.
Title: Epsin-Dependent Ligand Endocytosis Activates Notch by Force.
All of the data were consistent with a model where Epsin's essential function is to link ubiquitinated Notch ligands to Clathrin-coated vesicles through other Clathrin adapter proteins.
Title: Drosophila Epsin's role in Notch ligand cells requires three Epsin protein functions: the lipid binding function of the ENTH domain, a single Ubiquitin interaction motif, and a subset of the C-terminal protein binding modules.
Lqf is essential to the receptor-mediated endocytosis of larval serum proteins (LSPs) in the larval fat body cells of Drosophila.
Title: A novel role for the Drosophila epsin (lqf): involvement in autophagy.
Lqf plays distinct roles in two ubiquitin pathways to regulate structural and functional plasticity of the synapse
Title: The Drosophila epsin 1 is required for ubiquitin-dependent synaptic growth and function but not for synaptic vesicle recycling.
epsin plays a specific, evolutionarily conserved role to promote Notch signaling during animal development
Title: Epsin potentiates Notch pathway activity in Drosophila and C. elegans.
both Dmib and Epsin are required in these cells for some of the endocytic events that internalize DSL ligands
Title: Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila.
By deubiquitinating Lqf, which enhances the efficiency of Delta internalization, Faf stimulates Delta signaling
Title: Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells.
Epsin may be essential for Delta/Serrate/Lag2 signaling because it targets mono-ubiquitinated DSL proteins to an endocytic recycling compartment that they must enter to be converted into active ligands
Title: Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cardioblast cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
part_of clathrin vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: liquid facets

Names: CG8532-PA; CG8532-PB; CG8532-PC; CG8532-PD; CG8532-PE; CG8532-PF; CG8532-PG; CG8532-PH; CG8532-PI; CG8532-PJ; CG8532-PK; CG8532-PL; Epsin1/Liquid facets; Liquid-Facets; drosophila epsin; enhancer of faf bE25; epsin; epsin 1; lqf-PA; lqf-PB; lqf-PC; lqf-PD; lqf-PE; lqf-PF; lqf-PG; lqf-PH; lqf-PI; lqf-PJ; lqf-PK; lqf-PL

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

7528780..7540012

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274597.1 → NP_001261526.1 liquid facets, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261526.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KU93, Q9U741

Conserved Domains (2) summary

smart00726
Location:201 → 220

UIM; Ubiquitin-interacting motif

cd03571
Location:21 → 142

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
NM_001104059.2 → NP_001097529.1 liquid facets, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097529.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JNM3, Q9U740

Conserved Domains (1) summary

cd03571
Location:21 → 142

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
NM_206291.2 → NP_996013.1 liquid facets, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996013.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U741, Q9VS85

Conserved Domains (2) summary

smart00726
Location:208 → 227

UIM; Ubiquitin-interacting motif

cd03571
Location:28 → 149

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
NM_001274599.1 → NP_001261528.1 liquid facets, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261528.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEF2, Q9U741

Conserved Domains (2) summary

smart00726
Location:208 → 227

UIM; Ubiquitin-interacting motif

cd03571
Location:28 → 149

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
NM_001274598.1 → NP_001261527.1 liquid facets, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261527.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PBU6, Q9U740

Conserved Domains (1) summary

cd03571
Location:28 → 149

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
NM_079238.3 → NP_523962.2 liquid facets, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523962.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7KU90, Q9U741

Related

FBpp0076508

Conserved Domains (2) summary

smart00726
Location:201 → 220

UIM; Ubiquitin-interacting motif

cd03571
Location:21 → 142

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
NM_168221.3 → NP_729268.2 liquid facets, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729268.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7KU93, Q9U741

Related

FBpp0089150

Conserved Domains (2) summary

smart00726
Location:201 → 220

UIM; Ubiquitin-interacting motif

cd03571
Location:21 → 142

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
NM_001274596.1 → NP_001261525.1 liquid facets, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261525.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEM7, Q9U740

Conserved Domains (1) summary

cd03571
Location:21 → 142

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
NM_168219.1 → NP_729266.2 liquid facets, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729266.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9U741, Q9VS85

Related

FBpp0076509, FBtr0076795

Conserved Domains (2) summary

smart00726
Location:208 → 227

UIM; Ubiquitin-interacting motif

cd03571
Location:28 → 149

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
NM_168220.1 → NP_729267.1 liquid facets, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729267.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KU90, Q9U741

Related

FBpp0076510, FBtr0076796

Conserved Domains (2) summary

smart00726
Location:201 → 220

UIM; Ubiquitin-interacting motif

cd03571
Location:21 → 142

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
NM_001274600.1 → NP_001261529.1 liquid facets, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261529.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KU93, Q9U741

Conserved Domains (2) summary

smart00726
Location:201 → 220

UIM; Ubiquitin-interacting motif

cd03571
Location:21 → 142

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
NM_001274601.1 → NP_001261530.1 liquid facets, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261530.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEM7, Q9U740

Conserved Domains (1) summary

cd03571
Location:21 → 142

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A8JNM3		A8JNM3
M9PBU6		M9PBU6
M9PEF2		M9PEF2
M9PEM7		M9PEM7
Q7KU90		Q7KU90
Q7KU93		Q7KU93
Q8T0I6		Q8T0I6
Q9U740		Q9U740
Q9U741		Q9U741
Q9VS85		Q9VS85