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    Nle Notchless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33234, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nleprovided by FlyBase
    Official Full Name
    Notchlessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0021874
    Locus tag
    Dmel_CG2863
    See related
    AllianceGenome:FB:FBgn0021874
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0026364; CG2863; Dmel\CG2863; l(2)k13714; nle
    Summary
    Enables Notch binding activity. Involved in negative regulation of Notch signaling pathway and positive regulation of Notch signaling pathway. Predicted to be active in nucleolus. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; gut section; larval somatic muscle cell; and visceral mesoderm derivative. Orthologous to human NLE1 (notchless homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nle in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (566366..568121, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (566366..568121, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene reduced mechanoreceptor potential A Neighboring gene uncharacterized nascent polypeptide-associated complex beta subunit Neighboring gene Translocator protein Neighboring gene uncharacterized protein Neighboring gene Splicing factor 3b subunit 1 Neighboring gene Inositol phosphate kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation. Rørth P, et al. Mol Cell, 2000 Jul. PMID 10949024
    2. Notch signaling: a dance of proteins changing partners. Kadesch T. Exp Cell Res, 2000 Oct 10. PMID 11010805
    3. Relating past and present diet to phenotypic and transcriptomic variation in the fruit fly. May CM, et al. BMC Genomics, 2017 Aug 22. PMID 28830340, Free PMC Article
    4. Notchless encodes a novel WD40-repeat-containing protein that modulates Notch signaling activity. Royet J, et al. EMBO J, 1998 Dec 15. PMID 9857191, Free PMC Article
    5. Notch signaling in the nervous system. Pieces still missing from the puzzle. Baker NE. Bioessays, 2000 Mar. PMID 10684586

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Notch binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    notchless
    Names
    CG2863-PA
    Nle-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      566366..568121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057946.4 → NP_477294.2  notchless [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477294.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96995, Q8T4A2, Q9VPR4
      Related
      FBpp0077735
      Conserved Domains (5) summary
      COG2319
      Location:112 → 486
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:153 → 487
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam00400
      Location:110 → 147
      WD40; WD domain, G-beta repeat
      pfam08154
      Location:22 → 82
      NLE; NLE (NUC135) domain
      sd00039
      Location:164 → 202
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPR4.2 Q9VPR4

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