WSB1 WD repeat and SOCS box containing 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: WSB1provided by CGNC
Full Name: WD repeat and SOCS box containing 1provided by CGNC
Primary source: CGNC:4223
See related: Ensembl:ENSGALG00010029546
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: SWIP-1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	19	NC_052550.1 (9581185..9588657)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	19	NC_052591.1 (9317757..9325236)

Chromosome 19 - NC_052550.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the developing tibial growth plate, Hedgehog-stimulated D2 ubiquitination via ECS(WSB-1) induces parathyroid hormone-related peptide (PTHrP), thereby regulating chondrocyte differentiation.
Title: The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: WD repeat and SOCS box-containing protein 1

Names: SOCS box-containing WD protein SWiP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204872.2 → NP_990203.1 WD repeat and SOCS box-containing protein 1

See identical proteins and their annotated locations for NP_990203.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000323

UniProtKB/TrEMBL

Q9W7K9

Related

ENSGALP00010044108.1, ENSGALT00010071418.1

Conserved Domains (4) summary

COG2319
Location:38 → 382

WD40; WD40 repeat [General function prediction only]

cd00200
Location:135 → 388

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd03746
Location:382 → 421

SOCS_WSB1_SWIP1; SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 ...

sd00039
Location:134 → 168

7WD40; WD40 repeat [structural motif]