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    RPL23 ribosomal protein L23 [ Homo sapiens (human) ]

    Gene ID: 9349, updated on 10-Dec-2024

    Summary

    Official Symbol
    RPL23provided by HGNC
    Official Full Name
    ribosomal protein L23provided by HGNC
    Primary source
    HGNC:HGNC:10316
    See related
    Ensembl:ENSG00000125691 MIM:603662; AllianceGenome:HGNC:10316
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L23; uL14; rpL17
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 1299.4), bone marrow (RPKM 656.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RPL23 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (38847860..38853721, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (39710917..39716772, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37004113..37009974, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene microRNA 4727 Neighboring gene sperm microtubule associated protein 1 Neighboring gene uncharacterized LOC124903994 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:37008921-37010120 Neighboring gene small nucleolar RNA, H/ACA box 21B Neighboring gene small nucleolar RNA, H/ACA box 21 Neighboring gene ribosomal protein S20 pseudogene 35 Neighboring gene tRNA-Cys (anticodon GCA) 14-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, ribosomal protein L23 (RPL23), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies a structural ribosomal subunit RPL23 as IN-binding partner PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L23 (RPL23) at amino acid residues 62-63 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC72008, MGC111167, MGC117346

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables large ribosomal subunit rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin ligase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect G1 to G0 transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to actinomycin D IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein-DNA complex disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_positive_effect regulation of G1 to G0 transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribosomal protein import into nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    large ribosomal subunit protein uL14
    Names
    60S ribosomal protein L17
    60S ribosomal protein L23
    ribosomal protein L17

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000978.4NP_000969.1  large ribosomal subunit protein uL14

      See identical proteins and their annotated locations for NP_000969.1

      Status: REVIEWED

      Source sequence(s)
      AC110749, CA437923, X55954
      Consensus CDS
      CCDS11330.1
      UniProtKB/Swiss-Prot
      P23131, P24048, P62829, Q29246, Q3SWV7, Q6P5S1
      UniProtKB/TrEMBL
      Q9BTQ7
      Related
      ENSP00000420311.2, ENST00000479035.7
      Conserved Domains (1) summary
      PTZ00054
      Location:2139
      PTZ00054; 60S ribosomal protein L23; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      38847860..38853721 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      39710917..39716772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)