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    zormin zormin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2769001, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zorminprovided by FlyBase
    Official Full Name
    zorminprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052311
    Locus tag
    Dmel_CG33484
    See related
    AllianceGenome:FB:FBgn0052311
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH09541; CG11850; CG11952; CG11953; CG1282; CG32307; CG32309; CG32310; CG32311; CG33484; CG5699; CT36990; Dmel\CG33484; Zormin
    Summary
    Enables actin binding activity. Located in M band and Z disc. Is expressed in adult head; adult heart; indirect flight muscle cell; and spermatozoon. Orthologous to human CCDC141 (coiled-coil domain containing 141). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See zormin in Genome Data Viewer
    Location:
    62C4-62D1; 3-1.5 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2117466..2151700, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2117466..2151700, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene sallimus Neighboring gene antisense RNA:CR42860 Neighboring gene antisense RNA:CR45802 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Titin in insect spermatocyte spindle fibers associates with microtubules, actin, myosin and the matrix proteins skeletor, megator and chromator. Fabian L, et al. J Cell Sci, 2007 Jul 1. PMID 17591688
    2. The function of elastic proteins in the oscillatory contraction of insect flight muscle. Bullard B, et al. J Muscle Res Cell Motil, 2005. PMID 16450058
    3. Modular proteins from the Drosophila sallimus (sls) gene and their expression in muscles with different extensibility. Burkart C, et al. J Mol Biol, 2007 Apr 6. PMID 17316686
    4. The function of the M-line protein obscurin in controlling the symmetry of the sarcomere in the flight muscle of Drosophila. Katzemich A, et al. J Cell Sci, 2012 Jul 15. PMID 22467859, Free PMC Article
    5. Drosophila rolling pebbles colocalises and putatively interacts with alpha-Actinin and the Sls isoform Zormin in the Z-discs of the sarcomere and with Dumbfounded/Kirre, alpha-Actinin and Zormin in the terminal Z-discs. Kreisköther N, et al. J Muscle Res Cell Motil, 2006. PMID 16699917

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Z disc IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zormin
    Names
    CG33484-PE
    CG33484-PF
    CG33484-PG
    CG33484-PI
    CG33484-PJ
    CG33484-PK
    D-titin
    titin
    zormin-PE
    zormin-PF
    zormin-PG
    zormin-PI
    zormin-PJ
    zormin-PK

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2117466..2151700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043113.2 → NP_001036578.2  zormin, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036578.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8J5, Q7Z1Y4
      Conserved Domains (8) summary
      cd00096
      Location:1828 → 1892
      Ig; Immunoglobulin domain
      smart00408
      Location:1504 → 1570
      IGc2; Immunoglobulin C-2 Type
      COG0419
      Location:758 → 1386
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00176
      Location:134 → 332
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:1702 → 1786
      I-set; Immunoglobulin I-set domain
      cl02488
      Location:504 → 641
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl11960
      Location:2254 → 2324
      Ig; Immunoglobulin domain
      cl23720
      Location:1190 → 1311
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. NM_206240.2 → NP_995962.2  zormin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995962.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7Z1Y4, Q9W053
      Conserved Domains (8) summary
      pfam05483
      Location:523 → 1220
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd00096
      Location:2854 → 2921
      Ig; Immunoglobulin domain
      smart00408
      Location:1480 → 1546
      IGc2; Immunoglobulin C-2 Type
      cd00176
      Location:134 → 332
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:2837 → 2926
      I-set; Immunoglobulin I-set domain
      cl02488
      Location:504 → 641
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl11960
      Location:2230 → 2300
      Ig; Immunoglobulin domain
      cl23720
      Location:1166 → 1291
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    3. NM_001043112.2 → NP_001036577.2  zormin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036577.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8J4, Q7Z1Y4
      Conserved Domains (8) summary
      pfam05483
      Location:523 → 1220
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd00096
      Location:2998 → 3065
      Ig; Immunoglobulin domain
      smart00408
      Location:1480 → 1546
      IGc2; Immunoglobulin C-2 Type
      cd00176
      Location:126 → 332
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:2981 → 3070
      I-set; Immunoglobulin I-set domain
      cl02488
      Location:504 → 641
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl11960
      Location:2230 → 2300
      Ig; Immunoglobulin domain
      cl23720
      Location:1166 → 1291
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    4. NM_001043114.2 → NP_001036579.2  zormin, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036579.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8J3, Q7Z1Y4
      Conserved Domains (9) summary
      pfam05483
      Location:523 → 1220
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd00096
      Location:3559 → 3626
      Ig; Immunoglobulin domain
      smart00408
      Location:1480 → 1546
      IGc2; Immunoglobulin C-2 Type
      cd00176
      Location:126 → 332
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:3542 → 3631
      I-set; Immunoglobulin I-set domain
      pfam05672
      Location:1172 → 1290
      MAP7; MAP7 (E-MAP-115) family
      cl02488
      Location:504 → 641
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl11960
      Location:2230 → 2300
      Ig; Immunoglobulin domain
      cl23720
      Location:1166 → 1291
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    5. NM_001274388.1 → NP_001261317.1  zormin, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261317.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBJ1, Q7Z1Y4
      Conserved Domains (9) summary
      cd00096
      Location:3583 → 3650
      Ig; Immunoglobulin domain
      smart00408
      Location:1504 → 1570
      IGc2; Immunoglobulin C-2 Type
      COG1340
      Location:960 → 1298
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00176
      Location:126 → 332
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:3566 → 3655
      I-set; Immunoglobulin I-set domain
      pfam05672
      Location:1233 → 1365
      MAP7; MAP7 (E-MAP-115) family
      cl02488
      Location:504 → 641
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl11960
      Location:2254 → 2324
      Ig; Immunoglobulin domain
      cl23720
      Location:1190 → 1315
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    6. NM_001274386.1 → NP_001261315.1  zormin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261315.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE03, Q7Z1Y4
      Conserved Domains (8) summary
      cd00096
      Location:3455 → 3522
      Ig; Immunoglobulin domain
      smart00408
      Location:1520 → 1586
      IGc2; Immunoglobulin C-2 Type
      COG0419
      Location:774 → 1402
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00176
      Location:126 → 332
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:3438 → 3527
      I-set; Immunoglobulin I-set domain
      cl02488
      Location:504 → 657
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl11960
      Location:2270 → 2340
      Ig; Immunoglobulin domain
      cl23720
      Location:1206 → 1331
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBJ1 M9PBJ1
    M9PE03 M9PE03
    Q0E8J3 Q0E8J3
    Q0E8J4 Q0E8J4
    Q0E8J5 Q0E8J5
    Q7Z1Y4 Q7Z1Y4
    Q8SXC1 Q8SXC1
    Q9W053 Q9W053

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