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    bru2 bruno 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 250811, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bru2provided by FlyBase
    Official Full Name
    bruno 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0262475
    Locus tag
    Dmel_CG43065
    See related
    AllianceGenome:FB:FBgn0262475
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bru-2; Bru-2; CG17008; CG31761; CG31763; CG43065; CG6319; Dm Bru-2; Dmel\CG43065
    Old locus tag
    Dmel_CG31761; Dmel_CG31763
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA splice site recognition; negative regulation of translation; and regulation of alternative mRNA splicing, via spliceosome. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; mesoderm; and posterior endoderm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 97. Orthologous to human CELF1 (CUGBP Elav-like family member 1) and CELF2 (CUGBP Elav-like family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bru2 in Genome Data Viewer
    Location:
    33E1-33E3; 2-46 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12344219..12397528)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12344219..12397528)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45283 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Polycystic kidney disease 2 Neighboring gene virus-induced RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Bruno paralogue Bru-3 specifically binds the EDEN translational repression element. Delaunay J, et al. Nucleic Acids Res, 2004. PMID 15181172, Free PMC Article
    2. BrunoL1 regulates endoderm proliferation through translational enhancement of cyclin A2 mRNA. Horb LD, et al. Dev Biol, 2010 Sep 15. PMID 20633547, Free PMC Article
    3. 5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity. Bernstein AI, et al. Hum Mol Genet, 2016 Jun 15. PMID 27060332, Free PMC Article
    4. A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. Good PJ, et al. J Biol Chem, 2000 Sep 15. PMID 10893231
    5. The Genetic Architecture of Natural Variation in Recombination Rate in Drosophila melanogaster. Hunter CM, et al. PLoS Genet, 2016 Apr. PMID 27035832, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translation ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bruno 2
    Names
    CG43065-PA
    CG43065-PD
    CG43065-PE
    CG43065-PF
    CG43065-PG
    CG43065-PH
    CG43065-PI
    CG43065-PJ
    CG43065-PK
    CG43065-PL
    CG43065-PM
    bru2-PA
    bru2-PD
    bru2-PE
    bru2-PF
    bru2-PG
    bru2-PH
    bru2-PI
    bru2-PJ
    bru2-PK
    bru2-PL
    bru2-PM
    bruno-2
    bruno2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12344219..12397528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042891.3 → NP_001036356.1  bruno 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036356.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8R3
      Conserved Domains (3) summary
      cd12631
      Location:294 → 375
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12636
      Location:381 → 461
      RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins
      cl17169
      Location:801 → 892
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001259071.2 → NP_001246000.1  bruno 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246000.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF06
      Conserved Domains (2) summary
      cd12636
      Location:381 → 461
      RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins
      cl17169
      Location:294 → 375
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_176025.3 → NP_788039.1  bruno 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788039.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BL5
      Related
      FBpp0293399
      Conserved Domains (4) summary
      cd12631
      Location:294 → 375
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12636
      Location:381 → 461
      RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins
      TIGR01661
      Location:297 → 734
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:645 → 736
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_001273481.1 → NP_001260410.1  bruno 2, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260410.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BL5
      Conserved Domains (4) summary
      cd12631
      Location:294 → 375
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12636
      Location:381 → 461
      RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins
      TIGR01661
      Location:297 → 734
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:645 → 736
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. NM_135715.4 → NP_609559.1  bruno 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609559.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K108
      Related
      FBpp0293398
      Conserved Domains (2) summary
      cd12631
      Location:294 → 375
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12636
      Location:381 → 461
      RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins

    6. NM_001273482.1 → NP_001260411.1  bruno 2, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260411.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8R3
      Conserved Domains (3) summary
      cd12631
      Location:294 → 375
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12636
      Location:381 → 461
      RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins
      cl17169
      Location:801 → 892
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. NM_165007.3 → NP_723742.2  bruno 2, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723742.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF06
      Conserved Domains (2) summary
      cd12636
      Location:381 → 461
      RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins
      cl17169
      Location:294 → 375
      RRM_SF; RNA recognition motif (RRM) superfamily

    8. NM_001259069.2 → NP_001245998.1  bruno 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245998.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9ND73
      Conserved Domains (1) summary
      cl17169
      Location:294 → 332
      RRM_SF; RNA recognition motif (RRM) superfamily

    9. NM_001259070.1 → NP_001245999.1  bruno 2, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245999.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3H9
      Conserved Domains (2) summary
      cd12636
      Location:139 → 219
      RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins
      cl17169
      Location:559 → 650
      RRM_SF; RNA recognition motif (RRM) superfamily

    10. NM_001259073.1 → NP_001246002.1  bruno 2, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246002.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3H9
      Conserved Domains (2) summary
      cd12636
      Location:139 → 219
      RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins
      cl17169
      Location:559 → 650
      RRM_SF; RNA recognition motif (RRM) superfamily

    11. NM_001259072.1 → NP_001246001.1  bruno 2, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246001.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9EQV1, M9NCT8
      Conserved Domains (1) summary
      cl17169
      Location:258 → 349
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C1C3H9 C1C3H9
    M9NCT8 M9NCT8
    M9ND73 M9ND73
    M9NF06 M9NF06
    Q0E8R3 Q0E8R3
    Q7K108 Q7K108
    Q86BL5 Q86BL5

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