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    RapGAP1 Rap GTPase activating protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34032, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RapGAP1provided by FlyBase
    Official Full Name
    Rap GTPase activating protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0264895
    Locus tag
    Dmel_CG44086
    See related
    AllianceGenome:FB:FBgn0264895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13789; CG13790; CG13791; CG33529; CG34374; CG44086; CG6682; Dmel\CG44086; FBpp0111515; Q9VM02_DROME; rapgap; RapGAP; rapgap1; rapGAP1; Rapgap1; RapGap1
    Old locus tag
    CG13790; CG33529; Dmel_CG13790; Dmel_CG13791; Dmel_CG33529; Dmel_CG34374
    Summary
    Enables GTPase activator activity. Involved in negative regulation of small GTPase mediated signal transduction. Located in germ plasm. Is expressed in several structures, including efferent neurons; epithelium; germline cell; gut section; and head epidermis primordium. Orthologous to several human genes including RAP1GAP2 (RAP1 GTPase activating protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RapGAP1 in Genome Data Viewer
    Location:
    28A4-28B2; 2-27 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7497805..7578980, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7497805..7578980, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Zizimin Neighboring gene Odorant-binding protein 28a Neighboring gene long non-coding RNA:CR44082 Neighboring gene long non-coding RNA:CR46063 Neighboring gene long non-coding RNA:CR46535 Neighboring gene Serpin 28B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The molecular signature of BCR::ABL(P210) and BCR::ABL(T315I) in a Drosophila melanogaster chronic myeloid leukemia model. Baassiri A, et al. iScience, 2024 Apr 19. PMID 38585663, Free PMC Article
    2. Genomic mapping and expression patterns of C380, OK6 and D42 enhancer trap lines in the larval nervous system of Drosophila. Sanyal S. Gene Expr Patterns, 2009 Jun. PMID 19602393
    3. Rap1 GTPase promotes coordinated collective cell migration in vivo. Sawant K, et al. Mol Biol Cell, 2018 Nov 1. PMID 30156466, Free PMC Article
    4. Drosophila GoLoco-protein Pins is a target of Galpha(o)-mediated G protein-coupled receptor signaling. Kopein D, et al. Mol Biol Cell, 2009 Sep. PMID 19570914, Free PMC Article
    5. The Drosophila BMP type II receptor Wishful Thinking regulates neuromuscular synapse morphology and function. Marqués G, et al. Neuron, 2002 Feb 14. PMID 11856528

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c7550514-7548136 mobile_element_type = transposon:Burdock{}320

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of small GTPase mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of small GTPase mediated signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in germ plasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rap GTPase activating protein 1
    Names
    CG44086-PD
    CG44086-PE
    CG44086-PF
    CG44086-PH
    CG44086-PI
    RapGAP1-PD
    RapGAP1-PE
    RapGAP1-PF
    RapGAP1-PH
    RapGAP1-PI
    Rapgap1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7497805..7578980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103644.3 → NP_001097114.2  Rap GTPase activating protein 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097114.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYW8, O44090
      Conserved Domains (2) summary
      pfam02145
      Location:460 → 639
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:147 → 168
      GoLoco; GoLoco motif

    2. NM_144299.3 → NP_652556.2  Rap GTPase activating protein 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652556.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44090, Q9VM00
      Conserved Domains (2) summary
      pfam02145
      Location:434 → 613
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:121 → 142
      GoLoco; GoLoco motif

    3. NM_001273279.1 → NP_001260208.1  Rap GTPase activating protein 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260208.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44090, Q9VM00
      Conserved Domains (2) summary
      pfam02145
      Location:434 → 613
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:121 → 142
      GoLoco; GoLoco motif

    4. NM_001014479.2 → NP_001014479.1  Rap GTPase activating protein 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014479.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44090, Q59DZ5
      Conserved Domains (2) summary
      pfam02145
      Location:377 → 556
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:64 → 85
      GoLoco; GoLoco motif

    5. NM_001014478.2 → NP_001014478.1  Rap GTPase activating protein 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014478.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44090, Q9VM02
      Conserved Domains (1) summary
      pfam02145
      Location:351 → 530
      Rap_GAP; Rap/ran-GAP
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYW8 A8DYW8
    O44090 O44090
    Q59DZ5 Q59DZ5
    Q95SF4 Q95SF4
    Q9VM00 Q9VM00
    Q9VM02 Q9VM02

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