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    CG4230 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33743, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4230provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031683
    Locus tag
    Dmel_CG4230
    See related
    AllianceGenome:FB:FBgn0031683
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4230
    Summary
    Predicted to be involved in negative regulation of apoptotic process and regulation of actin filament polymerization. Predicted to be active in several cellular components, including apical plasma membrane; clathrin-coated vesicle; and sarcoplasmic reticulum. Is expressed in several structures, including adult head; antennal primordium; central brain primordium; ganglia; and head epidermis primordium. Human ortholog(s) of this gene implicated in severe congenital neutropenia 3. Orthologous to human HAX1 (HCLS1 associated protein X-1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4230 in Genome Data Viewer
    Location:
    25C6-25C6; 2-15 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5096227..5099294)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5096227..5099294)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 5 Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 13 kDa A subunit Neighboring gene Muscle-specific protein 300 kDa Neighboring gene small non-coding RNA 765 Neighboring gene small non-coding RNA 128

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Influence of the quick-to-court gene deletion on courtship behaviour of Drosophila melanogaster. G Belkina E, et al. J Genet, 2021. PMID 34238777
    2. NDR kinase tricornered genetically interacts with Ccm3 and metabolic enzymes in Drosophila melanogaster tracheal development. Hudson J, et al. G3 (Bethesda), 2023 Mar 9. PMID 36653023, Free PMC Article
    3. [Identification of C(2)M interacting proteins by yeast two-hybrid screening]. Yue SS, et al. Yi Chuan, 2015 Nov. PMID 26582530
    4. The genomic response to courtship song stimulation in female Drosophila melanogaster. Immonen E, et al. Proc Biol Sci, 2012 Apr 7. PMID 21976688, Free PMC Article
    5. Genetic basis and repeatability for desiccation resistance in Drosophila melanogaster (Diptera: Drosophilidae). Fanara JJ, et al. Genetica, 2024 Feb. PMID 38102503

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sarcoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4230-PA
    CG4230-PB
    CG4230-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5096227..5099294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135064.2 → NP_608908.1  uncharacterized protein Dmel_CG4230, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608908.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMU1
      Related
      FBpp0078658, FBtr0079019

    2. NM_001273157.1 → NP_001260086.1  uncharacterized protein Dmel_CG4230, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260086.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEP4

    3. NM_001273158.1 → NP_001260087.1  uncharacterized protein Dmel_CG4230, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260087.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB41
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PB41 M9PB41
    M9PEP4 M9PEP4
    Q9VMU1 Q9VMU1

    Gene LinkOut

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