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    dnr1 defense repressor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37575, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dnr1provided by FlyBase
    Official Full Name
    defense repressor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0260866
    Locus tag
    Dmel_CG12489
    See related
    AllianceGenome:FB:FBgn0260866
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12489; Dmel\CG12489; Dnr-1; dNR1; Dnr1; DNR1; Mylip
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in negative regulation of defense response to bacterium; proteasome-mediated ubiquitin-dependent protein catabolic process; and sleep. Predicted to be located in cytoskeleton. Is expressed in several structures, including antennal primordium; central brain primordium; head epidermis primordium; midline primordium; and ventral ectoderm. Used to study neurodegenerative disease. Orthologous to human MYLIP (myosin regulatory light chain interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dnr1 in Genome Data Viewer
    Location:
    58E9-58F1; 2-100 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22563152..22592964, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18450657..18480469, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene plexus Neighboring gene gasoline Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45328 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary rate patterns of genes involved in the Drosophila Toll and Imd signaling pathway. Han M, et al. BMC Evol Biol, 2013 Nov 8. PMID 24209511, Free PMC Article
    2. What RNAi screens in model organisms revealed about microbicidal response in mammals? Abnave P, et al. Front Cell Infect Microbiol, 2014. PMID 25629007, Free PMC Article
    3. Interactions of DNR1 with the apoptotic machinery of Drosophila melanogaster. Primrose DA, et al. J Cell Sci, 2007 Apr 1. PMID 17341581
    4. Dnr1-dependent regulation of the Drosophila immune deficiency signaling pathway. Guntermann S, et al. Dev Comp Immunol, 2009. PMID 18775745
    5. The mapping of Drosophila melanogaster mutant A.4.4. Bieser K, et al. MicroPubl Biol, 2018 Dec 17. PMID 32550366, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dnr1 is a negative regulator of the immune deficiency innate immune-response pathway. Dnr1 mutants exhibit shortened lifespan and progressive, age-dependent neuropathology associated with activation of the Imd pathway and elevated expression of AMP genes.
      Title: Dnr1 mutations cause neurodegeneration in Drosophila by activating the innate immune response in the brain.
    2. Dnr1 is a negative regulator of the Imd pathway
      Title: Dnr1-dependent regulation of the Drosophila immune deficiency signaling pathway.
    3. A study was made of the interactions of Dnr1 with the apoptotic machinery.
      Title: Interactions of DNR1 with the apoptotic machinery of Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of antibacterial peptide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    defense repressor 1
    Names
    CG12489-PA
    CG12489-PB
    defense repressor I
    dnr1-PA
    dnr1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22563152..22592964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274208.2 → NP_001261137.1  defense repressor 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261137.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFY0
      Conserved Domains (5) summary
      smart00295
      Location:3 → 143
      B41; Band 4.1 homologues
      cd13195
      Location:325 → 435
      FERM_C_MYLIP_IDOL; FERM domain C-lobe of E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP; also called inducible degrader of the LDL receptor, IDOL)
      pfam00373
      Location:93 → 143
      FERM_M; FERM central domain
      pfam09379
      Location:5 → 67
      FERM_N; FERM N-terminal domain
      pfam13920
      Location:544 → 589
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    2. NM_137836.3 → NP_611680.2  defense repressor 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611680.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SWW8, Q9W241
      Related
      FBpp0071748
      Conserved Domains (5) summary
      smart00295
      Location:3 → 143
      B41; Band 4.1 homologues
      cd13195
      Location:325 → 435
      FERM_C_MYLIP_IDOL; FERM domain C-lobe of E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP; also called inducible degrader of the LDL receptor, IDOL)
      pfam00373
      Location:93 → 143
      FERM_M; FERM central domain
      pfam09379
      Location:5 → 67
      FERM_N; FERM N-terminal domain
      pfam13920
      Location:544 → 589
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFY0 A0A0B4KFY0
    Q8SWW8 Q8SWW8

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