Ald1 Aldolase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ald1provided by FlyBase
Official Full Name: Aldolase 1provided by FlyBase
Primary source: FLYBASE:FBgn0000064
Locus tag: Dmel_CG6058
See related: AllianceGenome:FB:FBgn0000064
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ald; Ald; ALD; ALDOA; Aldolase; BcDNA:LP07735; CG6058; dALDOA; Dmel\CG6058; FBA; T12; T4; T6; T7
Summary: Enables fructose-1-phosphate aldolase activity and fructose-bisphosphate aldolase activity. Involved in several processes, including canonical glycolysis; fructose 1,6-bisphosphate metabolic process; and glucose homeostasis. Located in M band and Z disc. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; calyx of adult mushroom body; and embryonic/larval CNS perineurial glial cell. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system; hereditary fructose intolerance syndrome; and type 2 diabetes mellitus. Orthologous to several human genes including ALDOC (aldolase, fructose-bisphosphate C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (26254069..26261591, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (22079791..22087313, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables fructose-1-phosphate aldolase activity	IDA Inferred from Direct Assay more info	PubMed
enables fructose-bisphosphate aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose-bisphosphate aldolase activity	IDA Inferred from Direct Assay more info	PubMed
enables fructose-bisphosphate aldolase activity	IEA Inferred from Electronic Annotation more info
enables fructose-bisphosphate aldolase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical glycolysis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fructose 1,6-bisphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 1,6-bisphosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fructose catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glyceraldehyde-3-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in mesoderm development	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

Names: Ald1-PB; Ald1-PC; Ald1-PD; Ald1-PE; Ald1-PH; Ald1-PI; Ald1-PJ; Ald1-PK; Ald1-PL; Ald1-PM; CG6058-PB; CG6058-PC; CG6058-PD; CG6058-PE; CG6058-PH; CG6058-PI; CG6058-PJ; CG6058-PK; CG6058-PL; CG6058-PM; aldolase; fructose 1,6 biphosphate-aldolase A