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    MSBP membrane steroid binding protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32548, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MSBPprovided by FlyBase
    Official Full Name
    membrane steroid binding proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030703
    Locus tag
    Dmel_CG9066
    See related
    AllianceGenome:FB:FBgn0030703
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9066; Dmel\CG9066; dm_MSBP
    Summary
    Enables ecdysone binding activity. Located in plasma membrane. Is expressed in several structures, including adult head; adult heart; dorsal head epidermis; embryonic/larval corpus allatum; and embryonic/larval midgut primordium. Orthologous to several human genes including PGRMC1 (progesterone receptor membrane component 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MSBP in Genome Data Viewer
    Location:
    13F17-13F17; 1-52 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15887567..15890109, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15781600..15784142, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tay bridge Neighboring gene uncharacterized protein Neighboring gene shibire

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of the ecdysteroid-triggered growth arrest by a novel Drosophila membrane steroid binding protein. Fujii-Taira I, et al. FEBS Lett, 2009 Feb 18. PMID 19162019
    2. Microarray analysis of juvenile hormone response in Drosophila melanogaster S2 cells. Willis DK, et al. J Insect Sci, 2010. PMID 20672983, Free PMC Article
    3. Protein correlation profiles identify lipid droplet proteins with high confidence. Krahmer N, et al. Mol Cell Proteomics, 2013 May. PMID 23319140, Free PMC Article
    4. Mating-responsive genes in reproductive tissues of female Drosophila melanogaster. Mack PD, et al. Proc Natl Acad Sci U S A, 2006 Jul 5. PMID 16798875, Free PMC Article
    5. Stem Cell-Intrinsic, Seven-up-Triggered Temporal Factor Gradients Diversify Intermediate Neural Progenitors. Ren Q, et al. Curr Biol, 2017 May 8. PMID 28434858

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ecdysone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    membrane steroid binding protein
    Names
    CG9066-PA
    CG9066-PB
    CG9066-PC
    MSBP-PA
    MSBP-PB
    MSBP-PC
    steroid binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15887567..15890109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169294.2 → NP_001162765.1  membrane steroid binding protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162765.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXM4
      Conserved Domains (1) summary
      pfam00173
      Location:82 → 180
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    2. NM_132859.4 → NP_573087.1  membrane steroid binding protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573087.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXM4
      Related
      FBpp0073959
      Conserved Domains (1) summary
      pfam00173
      Location:82 → 180
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    3. NM_001272658.1 → NP_001259587.1  membrane steroid binding protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259587.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXM4
      Conserved Domains (1) summary
      pfam00173
      Location:82 → 180
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXM4 Q9VXM4

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