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    Ypel Yippee-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ypelprovided by FlyBase
    Official Full Name
    Yippee-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030183
    Locus tag
    Dmel_CG15309
    See related
    AllianceGenome:FB:FBgn0030183
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH10478; CG15309; Dmel\CG15309; dYPEL3; Ypel2
    Summary
    Involved in regulation of synapse organization. Used to study chromosome 16p11.2 deletion syndrome, 593-kb. Orthologous to several human genes including YPEL2 (yippee like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ypel in Genome Data Viewer
    Location:
    9B3-9B4; 1-31 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10205292..10212374, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10099325..10106407, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44894 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR32690 Neighboring gene long non-coding RNA:CR43899 Neighboring gene ATP synthase, delta subunit Neighboring gene antisense RNA:CR45629 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Frameshift mutations of YPEL3 alter the sensory circuit function in Drosophila. Kim JH, et al. Dis Model Mech, 2020 Jun 3. PMID 32461240, Free PMC Article
    2. Dissecting the complexity of CNV pathogenicity: insights from Drosophila and zebrafish models. Yusuff T, et al. Curr Opin Genet Dev, 2021 Jun. PMID 33812298, Free PMC Article
    3. Identification of novel candidate genes leading to sex differentiation in primordial germ cells of Drosophila. Ota R, et al. Gene Expr Patterns, 2023 Jun. PMID 37142099
    4. Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster. Iyer J, et al. Nat Commun, 2018 Jun 29. PMID 29959322, Free PMC Article
    5. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight. Cahill T, et al. Int J Mol Sci, 2021 Aug 31. PMID 34502375, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Yippee-like
    Names
    CG15309-PA
    CG15309-PB
    CG15309-PC
    CG15309-PD
    CG15309-PE
    Ypel-PA
    Ypel-PB
    Ypel-PC
    Ypel-PD
    Ypel-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10205292..10212374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272465.1 → NP_001259394.1  Yippee-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259394.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JUP6, Q9W2X7
      UniProtKB/TrEMBL
      K7X7R3
      Conserved Domains (1) summary
      cl13152
      Location:15 → 103
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    2. NM_001272466.1 → NP_001259395.1  Yippee-like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259395.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JUP6, Q9W2X7
      UniProtKB/TrEMBL
      K7X7R3
      Conserved Domains (1) summary
      cl13152
      Location:15 → 103
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    3. NM_001272467.1 → NP_001259396.1  Yippee-like, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259396.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JUP6, Q9W2X7
      UniProtKB/TrEMBL
      K7X7R3
      Conserved Domains (1) summary
      cl13152
      Location:15 → 103
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    4. NM_132381.4 → NP_572609.1  Yippee-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572609.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JUP6, Q9W2X7
      UniProtKB/TrEMBL
      K7X7R3
      Related
      FBpp0071416
      Conserved Domains (1) summary
      cl13152
      Location:15 → 103
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    5. NM_001103466.3 → NP_001096936.1  Yippee-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096936.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JUP6, Q9W2X7
      UniProtKB/TrEMBL
      K7X7R3
      Conserved Domains (1) summary
      cl13152
      Location:15 → 103
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    K7X7R3 K7X7R3
    Q9W2X7.1 Q9W2X7

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