fog folded gastrulation [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: fogprovided by FlyBase
Official Full Name: folded gastrulationprovided by FlyBase
Primary source: FLYBASE:FBgn0000719
Locus tag: Dmel_CG9559
See related: AllianceGenome:FB:FBgn0000719
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 114; CG9559; CR41108; CR41109; CR41110; Dmel\CG9559; Fog; l(1)114; l(1)16-3-190; l(1)20Ba; l114; M67
Summary: Enables G protein-coupled receptor binding activity and receptor ligand activity. Involved in several processes, including embryonic morphogenesis; mesectoderm development; and neurogenesis. Located in cytoplasm and extracellular space. Is expressed in several structures, including epithelium; glial cell; posterior midgut primordium; sensory organ cell; and wing disc. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 20E2-20F1; 1-66 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (22824317..22855194, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (22226153..22257030, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila Fog/Cta and T48 pathways have overlapping and distinct contributions to mesoderm invagination.
Title: Drosophila Fog/Cta and T48 pathways have overlapping and distinct contributions to mesoderm invagination.
Both genes are expressed and required for mesoderm invagination in the fruit fly Drosophila melanogaster but do not appear during mesoderm ingression of the midge Chironomus riparius.
Title: Folded gastrulation and T48 drive the evolution of coordinated mesoderm internalization in flies.
The mitochondria, through regulation of fusion and fission, function as downstream effectors and modulators of Fog signaling and Fog-dependent cell shape change.
Title: Signaling by Folded gastrulation is modulated by mitochondrial fusion and fission.
G protein-coupled receptor mist and its ligand fog have roles in regulating epithelial morphogenesis
Title: Regulation of epithelial morphogenesis by the G protein-coupled receptor mist and its ligand fog.
we propose that Gprk2 attenuates and tunes Fog-Cta signaling to prevent apical constriction in lateral mesodermal cells and to support appropriate apical constriction in ventral mesodermal cells.
Title: Gprk2 adjusts Fog signaling to organize cell movements in Drosophila gastrulation.
receptor tyrosine phosphatase PTP52F is a downstream component of the Fog signaling pathway in CNS neurons
Title: The secreted cell signal Folded Gastrulation regulates glial morphogenesis and axon guidance in Drosophila.
Fog protein is apically polarized and is both necessary and sufficient to drive apical myosin localization through a mechanism involving activation of myosin contractility with actin.
Title: folded gastrulation, cell shape change and the control of myosin localization.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c22833408-22833067 mobile_element_type = transposon:H{}2456
Loc: c22835198-22835099 mobile_element_type = transposon:INE-1{}3612
Loc: c22838652-22838603 mobile_element_type = transposon:INE-1{}3614
Loc: c22844466-22844314 mobile_element_type = transposon:INE-1{}3637
Loc: c22849807-22849281 mobile_element_type = transposon:INE-1{}3751

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in actin-mediated cell contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in apical constriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apical constriction involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apical constriction involved in ventral furrow formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesectoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	TAS Traceable Author Statement more info	PubMed
involved_in mesoderm migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in posterior midgut invagination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of development, heterochronic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myosin II filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland cavitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral furrow formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: folded gastrulation

Names: CG9559-PA; CG9559-PB; CG9559-PC; CG9559-PD; CG9559-PE; CG9559-PF; fog-PA; fog-PB; fog-PC; fog-PD; fog-PE; fog-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

22824317..22855194 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272855.2 → NP_001259784.1 folded gastrulation, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259784.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40795, Q9VR71

UniProtKB/TrEMBL

A4V4V8

Conserved Domains (1) summary

pfam15888
Location:58 → 166

FOG_N; Folded gastrulation N-terminus
NM_001272854.1 → NP_001259783.1 folded gastrulation, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259783.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40795, Q9VR71

UniProtKB/TrEMBL

A4V4V8

Conserved Domains (1) summary

pfam15888
Location:58 → 166

FOG_N; Folded gastrulation N-terminus
NM_001038771.3 → NP_001033860.1 folded gastrulation, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001033860.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40795, Q9VR71

UniProtKB/TrEMBL

A4V4V8

Conserved Domains (1) summary

pfam15888
Location:58 → 166

FOG_N; Folded gastrulation N-terminus
NM_001272852.1 → NP_001259781.1 folded gastrulation, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259781.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40795, Q9VR71

UniProtKB/TrEMBL

A4V4V8

Conserved Domains (1) summary

pfam15888
Location:58 → 166

FOG_N; Folded gastrulation N-terminus
NM_078714.6 → NP_523438.1 folded gastrulation, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523438.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40795, Q9VR71

UniProtKB/TrEMBL

A4V4V8

Related

FBpp0077034

Conserved Domains (1) summary

pfam15888
Location:58 → 166

FOG_N; Folded gastrulation N-terminus
NM_001272853.2 → NP_001259782.1 folded gastrulation, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259782.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40795, Q9VR71

UniProtKB/TrEMBL

A4V4V8

Conserved Domains (1) summary

pfam15888
Location:58 → 166

FOG_N; Folded gastrulation N-terminus