SRT2 sirtuin 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SRT2
Official Full Name: sirtuin 2
Primary source: TAIR:AT5G09230
Locus tag: AT5G09230
See related: Araport:AT5G09230
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtSRT2; sirtuin 2; SIRTUIN 2; T2K12.8
Summary: Encodes SRT2, a member of the SIR2 (sirtuin) family HDAC (histone deacetylase) (SRT1/AT5g55760, SRT2/AT5G09230).
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Genomic context

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See SRT2 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 11

Sequence:: Chromosome: 5; NC_003076.8 (2871365..2873789)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis thaliana sirtuins control proliferation and glutamate dehydrogenase activity.
Title: Arabidopsis thaliana sirtuins control proliferation and glutamate dehydrogenase activity.
This work establishes a mechanism by which histone deacetylases SRT1 and SRT2 interact with ENAP1 to mediate transcriptional repression by regulating the levels of histone H3 lysine 9 acetylation in the ethylene signaling
Title: Histone Deacetylases SRT1 and SRT2 Interact with ENAP1 to Mediate Ethylene-Induced Transcriptional Repression.
SRT2 is important in fine-tuning mitochondrial energy metabolism.
Title: The Arabidopsis class II sirtuin is a lysine deacetylase and interacts with mitochondrial energy metabolism.
AtSRT2 is a deacetylase that negatively regulates the plant basal defense and PR1 expression.
Title: Arabidopsis putative deacetylase AtSRT2 regulates basal defense by suppressing PAD4, EDS5 and SID2 expression.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001085081.2

Supported by ESTs:

NM_120959.4

Supported by ESTs:

NM_180464.4

Supported by ESTs:

NM_180465.3

Supported by ESTs:

NM_180466.4

Supported by ESTs:

NM_203024.3

Supported by ESTs:

NM_203025.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K9 acetyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ethylene-activated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of defense response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sirtuin 2

NP_001078550.1

sirtuin 2 (SRT2); FUNCTIONS IN: NAD binding, DNA binding, zinc ion binding, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; INVOLVED IN: chromatin silencing, defense response to bacterium, negative regulation of defense response, regulation of transcription, DNA-dependent; LOCATED IN: chromatin silencing complex, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent histone deacetylase, silent information regulator Sir2 (InterPro:IPR003000); BEST Arabidopsis thaliana protein match is: sirtuin 1 (TAIR:AT5G55760.1); Has 6471 Blast hits to 6454 proteins in 2013 species: Archae - 152; Bacteria - 3779; Metazoa - 822; Fungi - 681; Plants - 106; Viruses - 0; Other Eukaryotes - 931 (source: NCBI BLink).

NP_568207.1

sirtuin 2 (SRT2); FUNCTIONS IN: NAD binding, DNA binding, zinc ion binding, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; INVOLVED IN: chromatin silencing, defense response to bacterium, negative regulation of defense response, regulation of transcription, DNA-dependent; LOCATED IN: chromatin silencing complex, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent histone deacetylase, silent information regulator Sir2 (InterPro:IPR003000); BEST Arabidopsis thaliana protein match is: sirtuin 1 (TAIR:AT5G55760.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_850795.1

sirtuin 2 (SRT2); FUNCTIONS IN: NAD binding, DNA binding, zinc ion binding, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; INVOLVED IN: chromatin silencing, defense response to bacterium, negative regulation of defense response, regulation of transcription, DNA-dependent; LOCATED IN: chromatin silencing complex, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent histone deacetylase, silent information regulator Sir2 (InterPro:IPR003000); BEST Arabidopsis thaliana protein match is: sirtuin 1 (TAIR:AT5G55760.1); Has 6440 Blast hits to 6423 proteins in 1998 species: Archae - 152; Bacteria - 3742; Metazoa - 823; Fungi - 702; Plants - 106; Viruses - 0; Other Eukaryotes - 915 (source: NCBI BLink).

NP_850796.2

sirtuin 2 (SRT2); FUNCTIONS IN: NAD binding, DNA binding, zinc ion binding, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; INVOLVED IN: chromatin silencing, defense response to bacterium, negative regulation of defense response, regulation of transcription, DNA-dependent; LOCATED IN: chromatin silencing complex, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent histone deacetylase, silent information regulator Sir2 (InterPro:IPR003000); BEST Arabidopsis thaliana protein match is: sirtuin 1 (TAIR:AT5G55760.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_850797.1

sirtuin 2 (SRT2); FUNCTIONS IN: NAD binding, DNA binding, zinc ion binding, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; INVOLVED IN: chromatin silencing, defense response to bacterium, negative regulation of defense response, regulation of transcription, DNA-dependent; LOCATED IN: chromatin silencing complex, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent histone deacetylase, silent information regulator Sir2 (InterPro:IPR003000); BEST Arabidopsis thaliana protein match is: sirtuin 1 (TAIR:AT5G55760.1); Has 5572 Blast hits to 5555 proteins in 1862 species: Archae - 152; Bacteria - 3346; Metazoa - 798; Fungi - 483; Plants - 103; Viruses - 0; Other Eukaryotes - 690 (source: NCBI BLink).

NP_974753.1

sirtuin 2 (SRT2); FUNCTIONS IN: NAD binding, DNA binding, zinc ion binding, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; INVOLVED IN: chromatin silencing, defense response to bacterium, negative regulation of defense response, regulation of transcription, DNA-dependent; LOCATED IN: chromatin silencing complex, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent histone deacetylase, silent information regulator Sir2 (InterPro:IPR003000); BEST Arabidopsis thaliana protein match is: sirtuin 1 (TAIR:AT5G55760.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_974754.1

sirtuin 2 (SRT2); FUNCTIONS IN: NAD binding, DNA binding, zinc ion binding, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; INVOLVED IN: chromatin silencing, defense response to bacterium, negative regulation of defense response, regulation of transcription, DNA-dependent; LOCATED IN: chromatin silencing complex, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent histone deacetylase, silent information regulator Sir2 (InterPro:IPR003000); BEST Arabidopsis thaliana protein match is: sirtuin 1 (TAIR:AT5G55760.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

2871365..2873789

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_180464.4 → NP_850795.1 sirtuin 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850795.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B9DFU7, F4KCI0, Q94AQ6, Q9FY91

UniProtKB/TrEMBL

A0A5S9Y374, A0A654FZI4

Conserved Domains (1) summary

cd01409
Location:85 → 359

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
NM_203025.3 → NP_974754.1 sirtuin 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974754.1

Status: REVIEWED

UniProtKB/TrEMBL

F4KCI5

Conserved Domains (1) summary

cl00195
Location:28 → 257

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
NM_203024.3 → NP_974753.1 sirtuin 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974753.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UCZ7, A0A5S9Y374, A0A654FZI4

Conserved Domains (1) summary

cd01409
Location:66 → 340

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
NM_120959.4 → NP_568207.1 sirtuin 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568207.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B9DFU7, F4KCI0, Q94AQ6, Q9FY91

UniProtKB/TrEMBL

A0A5S9Y374, A0A654FZI4

Conserved Domains (1) summary

cd01409
Location:85 → 359

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
NM_180465.3 → NP_850796.2 sirtuin 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850796.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UCJ1, F4KCI3

Conserved Domains (1) summary

cl00195
Location:85 → 324

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
NM_180466.4 → NP_850797.1 sirtuin 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850797.1

Status: REVIEWED

UniProtKB/TrEMBL

F4KCI5

Conserved Domains (1) summary

cl00195
Location:28 → 257

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
NM_001085081.2 → NP_001078550.1 sirtuin 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078550.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9Y374, A0A654FZI4

Conserved Domains (1) summary

cd01409
Location:88 → 362

SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...