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    PUR5 phosphoribosylformylglycinamidine cyclo-ligase, chloroplast / phosphoribosyl-aminoimidazole synthetase / AIR synthase (PUR5) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824667, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PUR5
    Official Full Name
    phosphoribosylformylglycinamidine cyclo-ligase, chloroplast / phosphoribosyl-aminoimidazole synthetase / AIR synthase (PUR5)
    Primary source
    TAIR:AT3G55010
    Locus tag
    AT3G55010
    See related
    Araport:AT3G55010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPURM; EMB2818; EMBRYO DEFECTIVE 2818
    Summary
    encoding phosphoribosylformylglycinamidine cyclo-ligase (syn. AIR synthetase)that phosphorylates 5-phosphoribosyl-N-formylglycinamidine (FGAM) to form 5-aminoimidazole ribonucleotide (AIR)
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    Genomic context

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    See PUR5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (20386597..20388860)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene tonneau family protein Neighboring gene tonneau 1b (TON1b) Neighboring gene Ypt/Rab-GAP domain of gyp1p superfamily protein Neighboring gene phosphatidylglycerolphosphate synthase 2 Neighboring gene glutathione transferase lambda 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolating the Arabidopsis thaliana genes for de novo purine synthesis by suppression of Escherichia coli mutants. I. 5'-Phosphoribosyl-5-aminoimidazole synthetase. Senecoff JF, et al. Plant Physiol, 1993 Jun. PMID 8108507, Free PMC Article
    2. Molecular characterization of Arabidopsis thaliana cDNAs encoding three purine biosynthetic enzymes. Schnorr KM, et al. Plant J, 1994 Jul. PMID 7920700
    3. Analysis of the soluble ATP-binding proteome of plant mitochondria identifies new proteins and nucleotide triphosphate interactions within the matrix. Ito J, et al. J Proteome Res, 2006 Dec. PMID 17137349
    4. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article
    5. Proteomic analysis of the 26S proteasome reveals its direct interaction with transit peptides of plastid protein precursors for their degradation. Sako K, et al. J Proteome Res, 2014 Jul 3. PMID 24846764

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_115359.3
    NM_202708.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding HDA PubMed 
    enables copper ion binding HDA PubMed 
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine nucleotide biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    phosphoribosylformylglycinamidine cyclo-ligase, chloroplast / phosphoribosyl-aminoimidazole synthetase / AIR synthase (PUR5)
    NP_191061.1
    • PUR5; FUNCTIONS IN: phosphoribosylformylglycinamidine cyclo-ligase activity, copper ion binding, ATP binding; INVOLVED IN: purine nucleotide biosynthetic process; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: PurM, N-terminal-like (InterPro:IPR016188), AIR synthase related protein (InterPro:IPR000728), AIR synthase related protein, C-terminal (InterPro:IPR010918), Phosphoribosylformylglycinamidine cyclo-ligase (InterPro:IPR004733); Has 9318 Blast hits to 9280 proteins in 2601 species: Archae - 368; Bacteria - 5515; Metazoa - 245; Fungi - 143; Plants - 73; Viruses - 3; Other Eukaryotes - 2971 (source: NCBI BLink).
    NP_974437.1
    • PUR5; FUNCTIONS IN: phosphoribosylformylglycinamidine cyclo-ligase activity, copper ion binding, ATP binding; INVOLVED IN: purine nucleotide biosynthetic process; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: PurM, N-terminal-like (InterPro:IPR016188), AIR synthase related protein (InterPro:IPR000728), AIR synthase related protein, C-terminal (InterPro:IPR010918), Phosphoribosylformylglycinamidine cyclo-ligase (InterPro:IPR004733); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20386597..20388860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115359.3 → NP_191061.1  phosphoribosylformylglycinamidine cyclo-ligase, chloroplast / phosphoribosyl-aminoimidazole synthetase / AIR synthase (PUR5) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191061.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q05728, Q9M2W5, Q9SV49
      UniProtKB/TrEMBL
      A0A654FFW4
      Conserved Domains (2) summary
      cd02196
      Location:103 → 381
      PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
      PLN02557
      Location:16 → 389
      PLN02557; phosphoribosylformylglycinamidine cyclo-ligase

    2. NM_202708.2 → NP_974437.1  phosphoribosylformylglycinamidine cyclo-ligase, chloroplast / phosphoribosyl-aminoimidazole synthetase / AIR synthase (PUR5) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974437.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q05728, Q9M2W5, Q9SV49
      UniProtKB/TrEMBL
      A0A654FFW4
      Conserved Domains (2) summary
      cd02196
      Location:103 → 381
      PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
      PLN02557
      Location:16 → 389
      PLN02557; phosphoribosylformylglycinamidine cyclo-ligase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05728.2

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