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    MLO15 Seven transmembrane MLO family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819017, updated on 18-Sep-2024

    Summary

    Official Symbol
    MLO15
    Official Full Name
    Seven transmembrane MLO family protein
    Primary source
    TAIR:AT2G44110
    Locus tag
    AT2G44110
    See related
    Araport:AT2G44110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMLO15; F6E13.24; MILDEW RESISTANCE LOCUS O 15
    Summary
    A member of a large family of seven-transmembrane domain proteins specific to plants, homologs of the barley mildew resistance locus o (MLO) protein. The Arabidopsis genome contains 15 genes encoding MLO proteins, with localization in plasma membrane. Phylogenetic analysis revealed four clades of closely-related AtMLO genes. ATMLO15 belongs to the clade II, with ATMLO13 and ATMLO15. The gene is expressed during early seedling growth, in root tips and flower (papillae, anthers and pollen grains), as shown by GUS activity patterns. The expression of several phylogenetically closely-related AtMLO genes showed similar or overlapping tissue specificity and analogous responsiveness to external stimuli, suggesting functional redundancy, co-function, or antagonistic function(s).
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    Genomic context

    See MLO15 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    14
    Sequence:
    Chromosome: 2; NC_003071.7 (18245357..18248459, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Ankyrin repeat family protein Neighboring gene ncRNA Neighboring gene guanosine nucleotide diphosphate dissociation inhibitor 1 Neighboring gene Ribosomal protein L30/L7 family protein Neighboring gene Peptidase family C54 protein Neighboring gene Galactose oxidase/kelch repeat superfamily protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    Seven transmembrane MLO family protein
    NP_181939.1
    • MILDEW RESISTANCE LOCUS O 15 (MLO15); FUNCTIONS IN: calmodulin binding; INVOLVED IN: cell death, defense response; LOCATED IN: integral to membrane; EXPRESSED IN: male gametophyte, root tip, root, papillae; CONTAINS InterPro DOMAIN/s: Mlo-related protein (InterPro:IPR004326); BEST Arabidopsis thaliana protein match is: Seven transmembrane MLO family protein (TAIR:AT4G02600.2); Has 552 Blast hits to 534 proteins in 57 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 548; Viruses - 0; Other Eukaryotes - 4 (source: NCBI BLink).
    NP_973686.1
    • MILDEW RESISTANCE LOCUS O 15 (MLO15); FUNCTIONS IN: calmodulin binding; INVOLVED IN: cell death, defense response; LOCATED IN: integral to membrane; EXPRESSED IN: male gametophyte, root tip, root, papillae; CONTAINS InterPro DOMAIN/s: Mlo-related protein (InterPro:IPR004326); BEST Arabidopsis thaliana protein match is: Seven transmembrane MLO family protein (TAIR:AT4G02600.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18245357..18248459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_201957.2NP_973686.1  Seven transmembrane MLO family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973686.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VQX0, A0A654F6Y8, F4IT46
      Conserved Domains (1) summary
      pfam03094
      Location:5472
      Mlo; Mlo family
    2. NM_129974.1NP_181939.1  Seven transmembrane MLO family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181939.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80580
      UniProtKB/TrEMBL
      A0A654F6Y8
      Conserved Domains (1) summary
      pfam03094
      Location:9473
      Mlo; Mlo family