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    MAF4 K-box region and MADS-box transcription factor family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836631, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MAF4
    Official Full Name
    K-box region and MADS-box transcription factor family protein
    Primary source
    TAIR:AT5G65070
    Locus tag
    AT5G65070
    See related
    Araport:AT5G65070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AGAMOUS-like 69; AGL69; F15O5.3; F15O5_3; FCL4; MADS AFFECTING FLOWERING 4
    Summary
    Encodes MADS-box containing FLC paralog. Five splice variants have been identified but not characterized with respect to expression patterns and/or differing function. Overexpression of the gene in the Landsberg ecotype leads to a delay in flowering, transcript levels of MAF4 are reduced after a 6 week vernalization.
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    Genomic context

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    See MAF4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (25992193..25996202)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene AGAMOUS-like 31 Neighboring gene K-box region and MADS-box transcription factor family protein Neighboring gene K-box region/MADS-box transcription factor family protein Neighboring gene DNAse I-like superfamily protein Neighboring gene Ethylene insensitive 3 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global identification of Arabidopsis lncRNAs reveals the regulation of MAF4 by a natural antisense RNA. Zhao X, et al. Nat Commun, 2018 Nov 29. PMID 30498193, Free PMC Article
    2. Arabidopsis HUA ENHANCER 4 delays flowering by upregulating the MADS-box repressor genes FLC and MAF4. Ortuño-Miquel S, et al. Sci Rep, 2019 Feb 6. PMID 30728422, Free PMC Article
    3. The putative PRC1 RING-finger protein AtRING1A regulates flowering through repressing MADS AFFECTING FLOWERING genes in Arabidopsis. Shen L, et al. Development, 2014 Mar. PMID 24553292
    4. The AT-hook/PPC domain protein TEK negatively regulates floral repressors including MAF4 and MAF5. Xu Y, et al. Plant Signal Behav, 2013 Aug. PMID 23733063, Free PMC Article
    5. Analysis of the Arabidopsis MADS AFFECTING FLOWERING gene family: MAF2 prevents vernalization by short periods of cold. Ratcliffe OJ, et al. Plant Cell, 2003 May. PMID 12724541, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis HUA ENHANCER 4 delays flowering by upregulating the MADS-box repressor genes FLC and MAF4.
      Title: Arabidopsis HUA ENHANCER 4 delays flowering by upregulating the MADS-box repressor genes FLC and MAF4.
    2. MAS activates MAF4 by interacting with WDR5a, one core component of the COMPASS-like complexes, and recruiting WDR5a to MAF4 to enhance histone 3 lysine 4 trimethylation (H3K4me3
      Title: Global identification of Arabidopsis lncRNAs reveals the regulation of MAF4 by a natural antisense RNA.
    3. MADS AFFECTING FLOWERING 4 (MAF4) and MAF5 are also upregulated in TEK knockdown plants.
      Title: The AT-hook/PPC domain protein TEK negatively regulates floral repressors including MAF4 and MAF5.
    4. RING1A suppresses the expression of MAF4 and MAF5 through affecting H3K27me3 levels at these loci to regulate the floral transition
      Title: The putative PRC1 RING-finger protein AtRING1A regulates flowering through repressing MADS AFFECTING FLOWERING genes in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001126027.1
    NM_001203688.1
    NM_001345664.1
    NM_001345665.1
    NM_001345666.1
    NM_125906.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    K-box region and MADS-box transcription factor family protein
    NP_001119499.1
    • MADS AFFECTING FLOWERING 4 (MAF4); CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT5G65080.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_001190617.1
    • MADS AFFECTING FLOWERING 4 (MAF4); CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT5G65080.1).
    NP_201312.2
    • MADS AFFECTING FLOWERING 4 (MAF4); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: negative regulation of flower development; LOCATED IN: plasma membrane; EXPRESSED IN: cotyledon, hypocotyl; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT5G65080.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25992193..25996202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125906.4 → NP_201312.2  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201312.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0J8M0, C0J8M8, Q84NB2
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam01486
      Location:113 → 164
      K-box; K-box region

    2. NM_001345664.1 → NP_001332255.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BGG4, Q84NB1

    3. NM_001203688.1 → NP_001190617.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190617.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654GEB4, C0J8M0, C0J8M8, F4KGH9
      Conserved Domains (2) summary
      cd00265
      Location:2 → 61
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam01486
      Location:145 → 196
      K-box; K-box region

    4. NM_001345665.1 → NP_001332256.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BGI9

    5. NM_001126027.1 → NP_001119499.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119499.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0J8M0, C0J8M8, Q9LSR6
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam01486
      Location:144 → 194
      K-box; K-box region

    6. NM_001345666.1 → NP_001332257.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BGD0, A0A7G2FQ31
    Nucleotide Protein
    Heading Accession and Version

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