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    sncb synuclein, beta [ Danio rerio (zebrafish) ]

    Gene ID: 393944, updated on 9-Dec-2024

    Summary

    Official Symbol
    sncbprovided by ZNC
    Official Full Name
    synuclein, betaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1615
    See related
    Ensembl:ENSDARG00000104945 AllianceGenome:ZFIN:ZDB-GENE-040426-1615
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66343
    Summary
    Predicted to enable cuprous ion binding activity. Acts upstream of or within dopaminergic neuron differentiation and larval locomotory behavior. Predicted to be active in axon terminus; cytoplasm; and neuronal cell body. Is expressed in basal plate midbrain region; nervous system; pleuroperitoneal region; and trigeminal placode. Human ortholog(s) of this gene implicated in Lewy body dementia and Parkinson's disease. Orthologous to human SNCB (synuclein beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See sncb in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (50770537..50804042)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (45619305..45652810)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487628 Neighboring gene uncharacterized LOC137487540 Neighboring gene si:ch211-59p23.1 Neighboring gene G protein regulated inducer of neurite outgrowth 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Clone Names

    • MGC66343

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cuprous ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within dopaminergic neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within larval locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    beta-synuclein
    Names
    zSyn-&beta
    zSynC

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200969.1NP_957263.1  beta-synuclein

      See identical proteins and their annotated locations for NP_957263.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055608
      UniProtKB/TrEMBL
      A0A0R4INP0, B3DII6, Q7SX92
      Related
      ENSDARP00000135627.1, ENSDART00000158723.3
      Conserved Domains (1) summary
      pfam01387
      Location:1115
      Synuclein; Synuclein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      50770537..50804042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)