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    Ppp4r3a protein phosphatase 4, regulatory subunit 3A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314388, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppp4r3aprovided by RGD
    Official Full Name
    protein phosphatase 4, regulatory subunit 3Aprovided by RGD
    Primary source
    RGD:1309059
    See related
    EnsemblRapid:ENSRNOG00000027773 AllianceGenome:RGD:1309059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Smek1; RGD1309059
    Summary
    Predicted to enable protein phosphatase activator activity. Predicted to be involved in DNA damage response and regulation of double-strand break repair. Predicted to act upstream of or within positive regulation of gluconeogenesis and protein dephosphorylation. Predicted to be located in cytosol and nuclear speck. Predicted to be part of protein phosphatase 4 complex. Predicted to be active in nucleoplasm. Orthologous to human PPP4R3A (protein phosphatase 4 regulatory subunit 3A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 243.4), Spleen (RPKM 204.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp4r3a in Genome Data Viewer
    Location:
    6q32
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (126032068..126098329, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (120302508..120365907, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (125040803..125083496, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 68 Neighboring gene coiled-coil domain containing 88C Neighboring gene small ribosomal subunit protein uS2-like Neighboring gene ribosomal protein S3, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis. Yoon YS, et al. Proc Natl Acad Sci U S A, 2010 Oct 12. PMID 20876121, Free PMC Article
    2. Gene expression profile of the rat eye iridocorneal angle: NEIBank expressed sequence tag analysis. Ahmed F, et al. Invest Ophthalmol Vis Sci, 2004 Sep. PMID 15326124
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein phosphatase 4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase 4 complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 4 regulatory subunit 3A
    Names
    SMEK homolog 1, suppressor of mek1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108050.3 → NP_001101520.2  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform 2

      See identical proteins and their annotated locations for NP_001101520.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      FQ211523, JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6ARL9, A6JEI6
      Conserved Domains (2) summary
      pfam04802
      Location:166 → 357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:7 → 65
      PH-like; Pleckstrin homology-like domain

    2. NM_001271174.2 → NP_001258103.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      FQ211523, JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6ARL9, A0A8I6AS21
      Related
      ENSRNOP00000095747.1, ENSRNOT00000106200.2
      Conserved Domains (2) summary
      pfam04802
      Location:166 → 357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:7 → 65
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      126032068..126098329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261975.1 → XP_063118045.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X2

      UniProtKB/TrEMBL
      D4ABC4

    2. XM_039112354.2 → XP_038968282.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1

      UniProtKB/TrEMBL
      A0A8I6GJF4, D4ABC4
      Related
      ENSRNOP00000091226.1, ENSRNOT00000114004.2
      Conserved Domains (1) summary
      pfam04802
      Location:122 → 313
      SMK-1; Component of IIS longevity pathway SMK-1

    3. XM_039112355.2 → XP_038968283.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X3

      UniProtKB/TrEMBL
      D4ABC4
      Conserved Domains (1) summary
      pfam04802
      Location:42 → 233
      SMK-1; Component of IIS longevity pathway SMK-1

    4. XM_039112356.2 → XP_038968284.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X3

      UniProtKB/TrEMBL
      D4ABC4
      Related
      ENSRNOP00000038439.7, ENSRNOT00000034961.8
      Conserved Domains (1) summary
      pfam04802
      Location:42 → 233
      SMK-1; Component of IIS longevity pathway SMK-1

    5. XM_039112357.2 → XP_038968285.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X4

      Conserved Domains (3) summary
      pfam04802
      Location:166 → 357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:7 → 65
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:325 → 402
      Vitellogenin_N; Lipoprotein amino terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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