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    arid-1 AT-rich interactive domain-containing protein arid-1 [ Caenorhabditis elegans ]

    Gene ID: 4363100, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arid-1
    Official Full Name
    AT-rich interactive domain-containing protein arid-1
    Primary source
    WormBase:WBGene00044689
    Locus tag
    CELE_Y108G3AL.7
    See related
    AllianceGenome:WB:WBGene00044689
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transcription cis-regulatory region binding activity. Acts upstream of or within ERAD pathway and defense response to other organism. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to several human genes including ARID4A (AT-rich interaction domain 4A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See arid-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (186167..201297)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Pre-mRNA-splicing factor 38 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cullin family profile domain-containing protein;Cullin neddylation domain-containing protein;Cullin-3 Neighboring gene Trafficking protein particle complex subunit Neighboring gene Galectin;Galectin domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans. Tillman EJ, et al. Genetics, 2018 Dec. PMID 30287474, Free PMC Article
    2. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
    3. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to other organism IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to endoplasmic reticulum stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription repressor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    AT-rich interactive domain-containing protein arid-1
    NP_001041181.2
    • Confirmed by transcript evidence
    NP_001300004.1
    • Confirmed by transcript evidence
    NP_001300005.1
    • Confirmed by transcript evidence
    NP_001300006.1
    • Confirmed by transcript evidence
    NP_001300007.1
    • Confirmed by transcript evidence
    NP_001300008.1
    • Partially confirmed by transcript evidence
    NP_001300009.1
    • Confirmed by transcript evidence
    NP_001300010.1
    • Confirmed by transcript evidence
    NP_001300218.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      186167..201297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001313075.3 → NP_001300004.1  AT-rich interactive domain-containing protein arid-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0K3ARP6, A0A0K3AS59, A0A0K3AS65, A0A0K3AUK2, A0A0K3AV74, A0A0K3AVY5, A0A0K3AXH1, A0A0K3AXH5, G4SB35, Q95Y31
      Conserved Domains (1) summary
      smart01014
      Location:658 → 740
      ARID; ARID/BRIGHT DNA binding domain

    2. NM_001047716.4 → NP_001041181.2  AT-rich interactive domain-containing protein arid-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041181.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4SB35
      Conserved Domains (1) summary
      smart01014
      Location:658 → 740
      ARID; ARID/BRIGHT DNA binding domain

    3. NM_001313076.3 → NP_001300005.1  AT-rich interactive domain-containing protein arid-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AS59
      Conserved Domains (1) summary
      smart01014
      Location:611 → 693
      ARID; ARID/BRIGHT DNA binding domain

    4. NM_001313077.3 → NP_001300006.1  AT-rich interactive domain-containing protein arid-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUK2
      Conserved Domains (1) summary
      smart01014
      Location:611 → 693
      ARID; ARID/BRIGHT DNA binding domain

    5. NM_001313078.3 → NP_001300007.1  AT-rich interactive domain-containing protein arid-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARP6
      Conserved Domains (1) summary
      smart01014
      Location:1 → 77
      ARID; ARID/BRIGHT DNA binding domain

    6. NM_001313079.3 → NP_001300008.1  AT-rich interactive domain-containing protein arid-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AV74
      Conserved Domains (1) summary
      smart01014
      Location:1 → 77
      ARID; ARID/BRIGHT DNA binding domain

    7. NM_001313080.3 → NP_001300009.1  AT-rich interactive domain-containing protein arid-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AXH5

    8. NM_001313081.3 → NP_001300010.1  AT-rich interactive domain-containing protein arid-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AS65

    9. NM_001313289.3 → NP_001300218.1  AT-rich interactive domain-containing protein arid-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVY5
    Nucleotide Protein
    Heading Accession and Version

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