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    hrpu-1 B30.2/SPRY domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178421, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hrpu-1
    Official Full Name
    B30.2/SPRY domain-containing protein
    Primary source
    WormBase:WBGene00012769
    Locus tag
    CELE_Y41E3.11
    See related
    AllianceGenome:WB:WBGene00012769
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 54. Orthologous to several human genes including HNRNPU (heterogeneous nuclear ribonucleoprotein U) and HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hrpu-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (15039616..15049333)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene FANCD2 Neighboring gene ncRNA Neighboring gene putative elongation factor 1-beta/1-delta 2 Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class T Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity. Tabrez SS, et al. Nat Commun, 2017 Aug 21. PMID 28824175, Free PMC Article
    2. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    B30.2/SPRY domain-containing protein
    NP_001255853.1
    • Confirmed by transcript evidence
    NP_001255854.1
    • Confirmed by transcript evidence
    NP_001255855.1
    • Confirmed by transcript evidence
    NP_001255856.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      15039616..15049333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268924.3 → NP_001255853.1  B30.2/SPRY domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255853.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9WRU1
      Conserved Domains (4) summary
      smart00513
      Location:18 → 52
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PTZ00121
      Location:151 → 440
      PTZ00121; MAEBL; Provisional
      pfam13671
      Location:1168 → 1314
      AAA_33; AAA domain
      cl02614
      Location:946 → 1128
      SPRY; SPRY domain

    2. NM_001268925.3 → NP_001255854.1  B30.2/SPRY domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255854.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2H8
      Conserved Domains (2) summary
      pfam13671
      Location:418 → 564
      AAA_33; AAA domain
      cl02614
      Location:196 → 378
      SPRY; SPRY domain

    3. NM_001268926.3 → NP_001255855.1  B30.2/SPRY domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255855.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F5GUI4
      Conserved Domains (2) summary
      pfam13671
      Location:193 → 339
      AAA_33; AAA domain
      cl02614
      Location:1 → 153
      SPRY; SPRY domain

    4. NM_001268927.3 → NP_001255856.1  B30.2/SPRY domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255856.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F5GUI5

    RNA

    1. NR_131656.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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