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    thoc-5 THO complex subunit 5 [ Caenorhabditis elegans ]

    Gene ID: 175735, updated on 9-Dec-2024

    Summary

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    Official Symbol
    thoc-5
    Official Full Name
    THO complex subunit 5
    Primary source
    WormBase:WBGene00021311
    Locus tag
    CELE_Y32H12A.2
    See related
    AllianceGenome:WB:WBGene00021311
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be located in nucleus. Predicted to be part of THO complex part of transcription export complex. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human THOC5 (THO complex subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See thoc-5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (5345931..5349401, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Suppressor of organelle fusion 2 Neighboring gene R3H domain-containing protein Neighboring gene Glutaredoxin domain-containing protein Neighboring gene pseudo Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene Dehydrogenase/reductase SDR family member 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The glutaredoxin GLRX-21 functions to prevent selenium-induced oxidative stress in Caenorhabditis elegans. Morgan KL, et al. Toxicol Sci, 2010 Dec. PMID 20833709, Free PMC Article
    2. The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development. Castellano-Pozo M, et al. PLoS One, 2012. PMID 23285047, Free PMC Article
    3. Selenium induces cholinergic motor neuron degeneration in Caenorhabditis elegans. Estevez AO, et al. Neurotoxicology, 2012 Oct. PMID 22560997, Free PMC Article
    4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of THO complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    THO complex subunit 5
    NP_001254926.1
    • Confirmed by transcript evidence
    NP_001254927.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5345931..5349401 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267998.4 → NP_001254927.1  THO complex subunit 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254927.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C2BR94
      Conserved Domains (1) summary
      pfam09766
      Location:100 → 433
      FimP; Fms-interacting protein

    2. NM_001267997.3 → NP_001254926.1  THO complex subunit 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254926.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0N5
      Conserved Domains (1) summary
      pfam09766
      Location:100 → 431
      FimP; Fms-interacting protein
    Nucleotide Protein
    Heading Accession and Version

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