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    Y48E1B.3 Geranylgeranyl transferase type I subunit beta;Geranylgeranyl transferase type-1 subunit beta [ Caenorhabditis elegans ]

    Gene ID: 174999, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y48E1B.3
    Official Full Name
    Geranylgeranyl transferase type I subunit beta;Geranylgeranyl transferase type-1 subunit beta
    Primary source
    WormBase:WBGene00013002
    Locus tag
    CELE_Y48E1B.3
    See related
    AllianceGenome:WB:WBGene00013002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in RNA polymerase I preinitiation complex assembly. Predicted to be active in fibrillar center. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y48E1B.3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (13547739..13567971, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene G domain-containing protein Neighboring gene PIG-P domain-containing protein Neighboring gene WASH complex subunit homolog 1 Neighboring gene Large ribosomal subunit protein mL37 Neighboring gene C2H2-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables CAAX-protein geranylgeranyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase I core promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein geranylgeranyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase I preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in fibrillar center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Geranylgeranyl transferase type I subunit beta;Geranylgeranyl transferase type-1 subunit beta
    NP_001254397.1
    • Confirmed by transcript evidence
    NP_001254398.2
    • Partially confirmed by transcript evidence
    NP_001254400.1
    • Confirmed by transcript evidence
    NP_001367207.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13547739..13567971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267468.4 → NP_001254397.1  Geranylgeranyl transferase type-1 subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254397.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18197
      Conserved Domains (2) summary
      COG5029
      Location:30 → 354
      CAL1; Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism]
      cd02895
      Location:29 → 332
      GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...

    2. NM_001267471.3 → NP_001254400.1  Geranylgeranyl transferase type I subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254400.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7WNB0
      Conserved Domains (1) summary
      cl08267
      Location:1 → 167
      ISOPREN_C2_like; This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...

    3. NM_001267469.4 → NP_001254398.2  Geranylgeranyl transferase type I subunit beta [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7WNB1

    4. NM_001381645.1 → NP_001367207.1  Geranylgeranyl transferase type I subunit beta [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7WNB2
    Nucleotide Protein
    Heading Accession and Version

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