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    hum-7 Unconventional myosin-IXa-like [ Caenorhabditis elegans ]

    Gene ID: 171650, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hum-7
    Official Full Name
    Unconventional myosin-IXa-like
    Primary source
    WormBase:WBGene00002040
    Locus tag
    CELE_F56A6.2
    See related
    AllianceGenome:WB:WBGene00002040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables calmodulin binding activity and plus-end directed microfilament motor activity. Involved in actin-myosin filament sliding. Predicted to be part of myosin complex. Predicted to be active in actin filament. Is expressed in accessory cell; body wall musculature; and pharynx. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome. Orthologous to several human genes including MYO9A (myosin IXA). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hum-7 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    30
    Sequence:
    Chromosome: I; NC_003279.8 (585807..607571, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Crossover junction endonuclease MUS81;ERCC4 domain-containing protein Neighboring gene Piwi domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Head of myosin IX binds calmodulin and moves processively toward the plus-end of actin filaments. Liao W, et al. J Biol Chem, 2010 Aug 6. PMID 20538589, Free PMC Article
    2. The RhoGAP HUM-7/Myo9 integrates signals to modulate RHO-1/RhoA during embryonic morphogenesis in Caenorhabditiselegans. Wallace AG, et al. Development, 2018 Dec 3. PMID 30389847, Free PMC Article
    3. Unconventional Myosins from Caenorhabditis elegans as a Probe to Study Human Orthologues. Johnson CA, et al. Biomolecules, 2022 Dec 16. PMID 36551317, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RHO-1 activity is regulated by SAX-3/ROBO acting on the RhoGAP HUM-7.
      Title: The RhoGAP HUM-7/Myo9 integrates signals to modulate RHO-1/RhoA during embryonic morphogenesis in Caenorhabditiselegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables plus-end directed microfilament motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin-myosin filament sliding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Unconventional myosin-IXa-like
    NP_001248879.1
    • Confirmed by transcript evidence
    NP_001248880.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      585807..607571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001261951.3 → NP_001248880.1  Unconventional myosin-IXa-like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001248880.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0IWT2
      Conserved Domains (5) summary
      smart00242
      Location:163 → 936
      MYSc; Myosin. Large ATPases
      smart00314
      Location:28 → 134
      RA; Ras association (RalGDS/AF-6) domain
      cd00029
      Location:1475 → 1523
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01385
      Location:181 → 936
      MYSc_Myo9; class IX myosin, motor domain
      cl02570
      Location:1540 → 1727
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    2. NM_001261950.4 → NP_001248879.1  Unconventional myosin-IXa-like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001248879.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L082
      Conserved Domains (5) summary
      smart00242
      Location:163 → 936
      MYSc; Myosin. Large ATPases
      smart00314
      Location:28 → 134
      RA; Ras association (RalGDS/AF-6) domain
      cd00029
      Location:1462 → 1510
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01385
      Location:181 → 936
      MYSc_Myo9; class IX myosin, motor domain
      cl02570
      Location:1527 → 1714
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    Nucleotide Protein
    Heading Accession and Version

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